Forouzan Arash, Fahimi Mohammad Ali, Bastan Amir Sadegh Iran, Delirrooyfard Ali
Department of Emergency Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clinical Research Development Unit, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Adv Biomed Res. 2023 Mar 28;12:84. doi: 10.4103/abr.abr_122_21. eCollection 2023.
Due to the very high and increasing prevalence, essential complications, and risk factors for psychiatric disorders, it is necessary to introduce screening tests for diagnosing and predicting mild traumatic brain injury (mTBI) prognosis.
After completing the consent form and recording information and examination findings of patients with mild trauma, venous blood samples were taken from these patients. The samples were measured by observing the cold chain. After 3 months from mTBI, the post concussion symptoms questionnaire (PCSQ) and the short form 36 (SF-36) questionnaire for physical and mental evaluations were performed. Statistical tests analyzed the relationship between different variables and serum Creatine kinase BB (CKBB) levels.
Statistic analyses showed no relation between CKBB level of serum and age, gender, level of consciousness, PCSQ, and SF 36 scale, and the interval between trauma and arrival to the hospital. Further, there is a significant correlation between CK-BB levels and intracranial damage based on Fisher's exact test.
This study and following more significant considerations can introduce a serum-based biomarker panel that can accurately differentiate patients with complicated mTBI from those with uncomplicated.
由于精神疾病的患病率极高且不断上升，存在重要并发症和风险因素，因此有必要引入筛查测试来诊断和预测轻度创伤性脑损伤（mTBI）的预后。
在完成同意书并记录轻度创伤患者的信息和检查结果后，采集这些患者的静脉血样本。通过观察冷链对样本进行测量。在mTBI发生3个月后，进行用于身心评估的创伤后症状问卷（PCSQ）和简短健康调查36项量表（SF-36）问卷调查。统计测试分析了不同变量与血清肌酸激酶BB（CKBB）水平之间的关系。
统计分析表明，血清CKBB水平与年龄、性别、意识水平、PCSQ和SF-36量表以及创伤与入院之间的间隔时间无关。此外，基于Fisher精确检验，CK-BB水平与颅内损伤之间存在显著相关性。
本研究及后续更重要的考量可以引入一个基于血清的生物标志物组合，该组合能够准确区分复杂性mTBI患者和非复杂性mTBI患者。
