Coath William, Modat Marc, Cardoso M Jorge, Markiewicz Pawel J, Lane Christopher A, Parker Thomas D, Keshavan Ashvini, Buchanan Sarah M, Keuss Sarah E, Harris Matthew J, Burgos Ninon, Dickson John, Barnes Anna, Thomas David L, Beasley Daniel, Malone Ian B, Wong Andrew, Erlandsson Kjell, Thomas Benjamin A, Schöll Michael, Ourselin Sebastien, Richards Marcus, Fox Nick C, Schott Jonathan M, Cash David M
Dementia Research Centre UCL Queen Square Institute of Neurology London UK.
School of Biomedical Engineering and Imaging Sciences King's College London London UK.
Alzheimers Dement (Amst). 2023 May 16;15(2):e12434. doi: 10.1002/dad2.12434. eCollection 2023 Apr-Jun.
The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI).
We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling-derived cutpoints for Aβ PET positivity were converted.
The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM-based Centiloids. Linear adjustment produced a WM-based cutpoint of 18.1.
Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed.
Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.Centiloid values can be influenced by differences in acquisition.We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.Whole cerebellum referenced values could be reliably transformed to Centiloids.White matter referenced values may be less generalizable between datasets.
百分制量表旨在统一不同分析方法下的淀粉样β蛋白（Aβ）正电子发射断层扫描（PET）测量结果。由于百分制量表是使用PET/计算机断层扫描（CT）数据创建的，且受扫描仪差异影响，我们使用通过PET/磁共振成像（MRI）采集的Insight 46数据研究了百分制转换。
我们对432例使用全小脑（WC）和白质（WM）参考进行处理的氟代硼吡咯PET/MRI扫描的标准化摄取值比率（SUVR）进行了转换，转换时考虑了有无部分容积校正的情况。对通过高斯混合模型得出的Aβ PET阳性切点进行了转换。
WC SUVR的百分制切点为14.2。校准数据集和测试数据集之间WM和WC摄取之间的关系有所不同，导致基于WM的百分制量表值低得不合理。线性调整后得出基于WM的切点为18.1。
将PET/MRI氟代硼吡咯数据转换为百分制量表是有效的。然而，需要进一步了解使用WM参考时采集或生物学因素对转换的影响。
淀粉样β蛋白正电子发射断层扫描（PET）数据的百分制转换旨在使结果标准化。百分制值可能受采集差异的影响。我们转换了来自一个大型出生队列的氟代硼吡咯PET/磁共振成像数据。全小脑参考值可以可靠地转换为百分制量表值。白质参考值在不同数据集之间的通用性可能较差。
