MOGAD 脊髓炎的显著中央管 T2 高信号与 NMOSD 和 MS 的比较。
Marked central canal T2-hyperintensity in MOGAD myelitis and comparison to NMOSD and MS.
机构信息
Department of Neurology, Mayo Clinic College of Medicine, 200 1(st) St. SW, Rochester, MN, USA.
Department of Radiology, Mayo Clinic College of Medicine, 200 1(st) St. SW, Rochester, MN, USA.
出版信息
J Neurol Sci. 2023 Jul 15;450:120687. doi: 10.1016/j.jns.2023.120687. Epub 2023 May 12.
OBJECTIVE
To assess marked central canal T2-hyperintensity in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) myelitis compared to myelitis patients with aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and multiple sclerosis (MS).
MATERIAL/METHODS: Two blinded raters evaluated spinal cord magnetic resonance imaging (MRIs) of myelitis patients with MOGAD (n = 63), AQP4 + NMOSD (n = 37), and MS (n = 26), assessing for marked central canal T2-hyperintensity and its evolution. If there were conflicting results, a third neurologist assessed the MRI.
RESULTS
Marked central canal T2-hyperintensity was more frequent in patients with MOGAD (18/63[29%]) than MS (1/26[4%]; p = 0.01) myelitis but did not differ from AQP4 + NMOSD (13/37[35%]; p = 0.49). Marked central canal T2-hyperintensity had completely resolved on follow-up axial MRI for most MOGAD (12/14[86%]) and AQP4 + NMOSD (10/10[100%]; p = 0.49) patients.
CONCLUSIONS
Marked central canal T2-hyperintensity is a common transient radiologic accompaniment of MOGAD and AQP4 + NMOSD myelitis, but not MS myelitis.
目的
评估髓鞘少突胶质细胞糖蛋白抗体相关性疾病（MOGAD）性脊髓炎患者与水通道蛋白 4 抗体阳性视神经脊髓炎谱系疾病（AQP4+NMOSD）和多发性硬化（MS）性脊髓炎患者相比，中央管 T2 高信号的显著程度。
材料/方法：两名盲法评估者评估了 MOGAD（n=63）、AQP4+NMOSD（n=37）和 MS（n=26）性脊髓炎患者的脊髓磁共振成像（MRI），评估中央管 T2 高信号的显著程度及其演变。如果存在不一致的结果，由第三位神经科医生评估 MRI。
结果
MOGAD（18/63[29%]）性脊髓炎患者的中央管 T2 高信号比 MS（1/26[4%]；p=0.01）性脊髓炎更常见，但与 AQP4+NMOSD（13/37[35%]；p=0.49）性脊髓炎无差异。大多数 MOGAD（12/14[86%]）和 AQP4+NMOSD（10/10[100%]；p=0.49）患者的随访轴位 MRI 显示中央管 T2 高信号完全消退。
结论
中央管 T2 高信号是 MOGAD 和 AQP4+NMOSD 性脊髓炎的常见短暂放射学伴随表现，但不是 MS 性脊髓炎的伴随表现。
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