Department of Neurology, Mayo Clinic College of Medicine, 200 1(st) St. SW, Rochester, MN, USA.
Department of Radiology, Mayo Clinic College of Medicine, 200 1(st) St. SW, Rochester, MN, USA.
J Neurol Sci. 2023 Jul 15;450:120687. doi: 10.1016/j.jns.2023.120687. Epub 2023 May 12.
To assess marked central canal T2-hyperintensity in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) myelitis compared to myelitis patients with aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and multiple sclerosis (MS).
MATERIAL/METHODS: Two blinded raters evaluated spinal cord magnetic resonance imaging (MRIs) of myelitis patients with MOGAD (n = 63), AQP4 + NMOSD (n = 37), and MS (n = 26), assessing for marked central canal T2-hyperintensity and its evolution. If there were conflicting results, a third neurologist assessed the MRI.
Marked central canal T2-hyperintensity was more frequent in patients with MOGAD (18/63[29%]) than MS (1/26[4%]; p = 0.01) myelitis but did not differ from AQP4 + NMOSD (13/37[35%]; p = 0.49). Marked central canal T2-hyperintensity had completely resolved on follow-up axial MRI for most MOGAD (12/14[86%]) and AQP4 + NMOSD (10/10[100%]; p = 0.49) patients.
Marked central canal T2-hyperintensity is a common transient radiologic accompaniment of MOGAD and AQP4 + NMOSD myelitis, but not MS myelitis.
评估髓鞘少突胶质细胞糖蛋白抗体相关性疾病（MOGAD）性脊髓炎患者与水通道蛋白 4 抗体阳性视神经脊髓炎谱系疾病（AQP4+NMOSD）和多发性硬化（MS）性脊髓炎患者相比，中央管 T2 高信号的显著程度。
材料/方法：两名盲法评估者评估了 MOGAD（n=63）、AQP4+NMOSD（n=37）和 MS（n=26）性脊髓炎患者的脊髓磁共振成像（MRI），评估中央管 T2 高信号的显著程度及其演变。如果存在不一致的结果，由第三位神经科医生评估 MRI。
MOGAD（18/63[29%]）性脊髓炎患者的中央管 T2 高信号比 MS（1/26[4%]；p=0.01）性脊髓炎更常见，但与 AQP4+NMOSD（13/37[35%]；p=0.49）性脊髓炎无差异。大多数 MOGAD（12/14[86%]）和 AQP4+NMOSD（10/10[100%]；p=0.49）患者的随访轴位 MRI 显示中央管 T2 高信号完全消退。
中央管 T2 高信号是 MOGAD 和 AQP4+NMOSD 性脊髓炎的常见短暂放射学伴随表现，但不是 MS 性脊髓炎的伴随表现。
