Noguchi-Shinohara Moeko, Murakami Hidetomo, Sakashita Yasuhiro, Mori Yukiko, Komatsu Junji, Muramatsu Daiki, Hikishima Sadao, Ono Kenjiro
Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Department of Neurology, School of Medicine, Showa University, Tokyo, Japan.
Parkinsonism Relat Disord. 2023 Jun;111:105445. doi: 10.1016/j.parkreldis.2023.105445. Epub 2023 May 13.
No blood biomarkers which can identify Alzheimer's disease pathology in Lewy body disease (LBD) have ever been established. We showed that the plasma amyloid-β (Aβ) /Aβ ratio was significantly decreased in patients with Aβ+ LBD compared with those with Aβ- LBD and it might be a useful biomarker.
目前尚未建立能够识别路易体病（LBD）中阿尔茨海默病病理特征的血液生物标志物。我们发现，与Aβ阴性的LBD患者相比，Aβ阳性的LBD患者血浆淀粉样蛋白-β（Aβ）/Aβ比值显著降低，它可能是一种有用的生物标志物。
