Faculty of Pharmacy, Middle East University, Amman 11831, Jordan; Applied Science Research Center. Applied Science Private University, Amman, Jordan.
Virology Department, Faculty of Veterinary Medicine, The University of Tehran, Tehran, Iran.
Pathol Res Pract. 2023 Jul;247:154522. doi: 10.1016/j.prp.2023.154522. Epub 2023 May 8.
Exosomes are now significant players in both healthy and unhealthy cell-to-cell communication. Exosomes can mediate immune activation or immunosuppression, which can influence the growth of tumors. Exosomes affect the immune responses to malignancies in various ways by interacting with tumor cells and the environment around them. Exosomes made by immune cells can control the growth, metastasis, and even chemosensitivity of tumor cells. In contrast, exosomes produced by cancer cells can encourage immune responses that support the tumor. Exosomes carry circular RNAs, long non-coding RNAs, and microRNAs (miRNAs), all involved in cell-to-cell communication. In this review, we focus on the most recent findings concerning the role of exosomal miRNAs, lncRNAs, and circRNAs in immune modulation and the potential therapeutic implications of these discoveries.
外泌体现在是细胞间通讯中健康和不健康的重要参与者。外泌体可以介导免疫激活或免疫抑制，这可能会影响肿瘤的生长。外泌体通过与肿瘤细胞及其周围环境相互作用，以各种方式影响对恶性肿瘤的免疫反应。免疫细胞产生的外泌体可以控制肿瘤细胞的生长、转移，甚至化疗敏感性。相反，癌细胞产生的外泌体可以促进支持肿瘤的免疫反应。外泌体携带环状 RNA、长非编码 RNA 和 microRNAs（miRNAs），所有这些都参与细胞间通讯。在这篇综述中，我们重点介绍了外泌体 miRNAs、lncRNAs 和 circRNAs 在免疫调节中的最新发现，以及这些发现的潜在治疗意义。
