Shakhpazyan Nikolay K, Mikhaleva Liudmila M, Bedzhanyan Arcady L, Sadykhov Nikolay K, Midiber Konstantin Y, Konyukova Alexandra K, Kontorschikov Andrey S, Maslenkina Ksenia S, Orekhov Alexander N
Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435 Moscow, Russia.
Department of Abdominal Surgery and Oncology II (Coloproctology and Uro-Gynecology), Petrovsky National Research Center of Surgery, 119435 Moscow, Russia.
Biomedicines. 2023 Aug 28;11(9):2411. doi: 10.3390/biomedicines11092411.
This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.
这篇综述全面阐述了长链非编码RNA（lncRNAs）在结直肠癌（CRC）微环境中的复杂作用，涉及免疫、细胞间通讯和治疗潜力等领域。lncRNAs在CRC的发病机制、免疫逃逸及对CRC的治疗反应中发挥着重要作用，对炎症具有关键影响，有望成为新型治疗策略和生物标志物的候选分子。本综述审视了lncRNAs与CRC共识分子亚型（CMSs）的相互作用、它们与影响免疫和炎症的肿瘤基质的复杂相互作用，以及它们通过细胞外囊泡（特别是外泌体）的转运。此外，我们深入探讨了lncRNAs与其他非编码RNA（包括微小RNA和环状RNA）在CRC微环境中介导细胞间通讯的复杂关系。最后，我们提出了操纵lncRNAs以增强抗肿瘤免疫力的潜在策略，从而突出了lncRNAs在设计CRC创新治疗干预措施中的重要性。
