Bates A K, Cheng H, Hiorns R W
Curr Eye Res. 1986 May;5(5):363-6. doi: 10.3109/02713688609025174.
Patients involved in a clinical trial of cataract surgery who developed pseudophakic bullous keratopathy were studied. They did not differ from the trial population as a whole with respect to their age or pre-operative endothelial cell density. Bullous keratopathy occurred within a narrow range of endothelial cell density. Examination of endothelial cell loss profiles over four years of follow-up after cataract surgery, in patients who developed bullous keratopathy and others, suggested that there was a predictable pattern. A mathematical model is described which gave good agreement between predicted and measured endothelial cell density. The model is now being used to identify parameters which may predict susceptibility to development of bullous keratopathy.
对参与白内障手术临床试验且发生了人工晶状体性大泡性角膜病变的患者进行了研究。他们在年龄或术前内皮细胞密度方面与整个试验人群并无差异。大泡性角膜病变发生在内皮细胞密度的一个狭窄范围内。对发生大泡性角膜病变的患者和其他患者在白内障手术后四年随访期间的内皮细胞丢失情况进行检查，结果表明存在一种可预测的模式。描述了一个数学模型，该模型预测的内皮细胞密度与测量值之间具有良好的一致性。目前正在使用该模型来确定可能预测发生大泡性角膜病变易感性的参数。
