Zs-Nagy I, Pieri C, Giuli C, Del Moro M
Gerontology. 1979;25(2):94-102. doi: 10.1159/000212326.
The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased the potassium content in both the nucleus and cytoplasm in terms of dry mass fraction, whereas the sodium concentration remained unchanged. The Na+/K+ ration increased significantly in both cell compartments. The chloride content of the nuclei decreased slightly. If one supposes just 1--2% rehydration of the old cytoplasm, the decrease of the total ionic strength may be of considerable extent, it may even reach the values obtained in young adult animals. The results are interpreted in terms of a recently developed 'membrane hypothesis' of aging.
通过能量色散X射线微分析，研究了盐酸甲氯芬酯对老年雌性Wistar大鼠大脑皮质细胞单价电解质含量的影响。以腹腔注射100mg/kg体重的形式给药该药物，持续20天。就干质量分数而言，治疗降低了细胞核和细胞质中的钾含量，而钠浓度保持不变。两个细胞区室中的Na+/K+比值均显著增加。细胞核中的氯含量略有下降。如果假设老年细胞质仅再水化1%-2%，总离子强度的降低可能相当显著，甚至可能达到年轻成年动物所获得的值。根据最近提出的衰老“膜假说”对结果进行了解释。
