Zs-Nagy I, Semsei I
Exp Gerontol. 1984;19(3):171-8. doi: 10.1016/0531-5565(84)90035-4.
The rates of total and polyA+ RNA (mRNA) synthesis were measured by radioisotope technique in the brain cortex of female CFY rats. There was practically no significant difference between the young (1.5 months) and adult (13 months) rats; however, the old group (26 months) displayed a considerable decrease of the rates of synthesis of both classes of RNA studied. Centrophenoxine treatment (100 mg per kg body weight per day, for 2 months) reversed this tendency, and increased significantly the synthesis rates of old rats almost to the adult level. The results are interpreted in terms of the membrane hypothesis of aging, attributing a free-radical scavenger function of the dimethylamino-ethanol incorporated into the nerve cell membrane from the centrophenoxine.
采用放射性同位素技术测定了雌性CFY大鼠大脑皮层中总RNA和聚腺苷酸加尾RNA（mRNA）的合成速率。幼年（1.5个月）和成年（13个月）大鼠之间几乎没有显著差异；然而，老年组（26个月）所研究的两类RNA的合成速率显著降低。中枢酚（每天每千克体重100毫克，持续2个月）治疗扭转了这种趋势，并使老年大鼠的合成速率显著提高，几乎达到成年水平。根据衰老的膜假说对结果进行了解释，认为中枢酚中所含的二甲基氨基乙醇具有自由基清除功能，可掺入神经细胞膜。
