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基于四苯乙烯标记壳聚糖和六羧基化三亚苯并三蝶烯的pH响应型荧光超分子纳米颗粒

pH-Responsive fluorescent supramolecular nanoparticles based on tetraphenylethylene-labelled chitosan and a six-fold carboxylated tribenzotriquinacene.

作者信息

Yang Nan, Zhu Yi-Yan, Lin Wei-Xiu, Lu Yi-Long, Xu Wen-Rong

机构信息

Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, Hainan Provincial Key Laboratory of Fine Chemistry, School of Chemical Engineering and Technology, School of Science, Hainan University, Haikou 570228, PR China.

出版信息

Beilstein J Org Chem. 2023 May 8;19:635-645. doi: 10.3762/bjoc.19.45. eCollection 2023.

DOI:10.3762/bjoc.19.45
PMID:37205131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10186267/
Abstract

We synthesized a new tetraphenylethylene-modified chitosan bioconjugate, , that shows the aggregation-induced emission effect. It can self-assemble into fluorescent polymeric nanoparticles in an aqueous solution at pH 5.3 either alone or with the water-soluble bowl-shaped six-fold carboxylated tribenzotriquinacene derivative via host-guest binding. The spherical nanoparticles formed by amphiphiles or supra-amphiphiles disintegrated under alkaline stimulation at pH 10.4 and the dispersion of the aggregates after the collapse in the presence of was greatly improved. In addition, the fluorescence of was significantly enhanced by introducing , and remained relatively stable with variations in pH for both and /. Such pH-responsive supramolecular spherical nanoparticles with stable fluorescence emission based on or may find applications in various fields, including the development of visual oral drug delivery systems.

摘要

我们合成了一种新的四苯乙烯修饰的壳聚糖生物共轭物，其显示出聚集诱导发光效应。它在pH 5.3的水溶液中，无论是单独存在还是与水溶性碗状六重羧基化三苯并三喹啉衍生物通过主客体结合，都能自组装成荧光聚合物纳米颗粒。由两亲物或超两亲物形成的球形纳米颗粒在pH 10.4的碱性刺激下分解，并且在存在[具体物质未明确]的情况下，坍塌后聚集体的分散性得到了极大改善。此外，通过引入[具体物质未明确]，[共轭物名称未明确]的荧光显著增强，并且对于[共轭物名称未明确]和[另一种共轭物名称未明确]而言，其荧光在pH变化时都保持相对稳定。这种基于[共轭物名称未明确]或[另一种共轭物名称未明确]的具有稳定荧光发射的pH响应超分子球形纳米颗粒可能在包括视觉口服药物递送系统开发在内的各个领域找到应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/db03da975f2a/Beilstein_J_Org_Chem-19-635-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/79ecf523d156/Beilstein_J_Org_Chem-19-635-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/e2e65812133a/Beilstein_J_Org_Chem-19-635-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/86ec41302cf9/Beilstein_J_Org_Chem-19-635-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/90878d60737a/Beilstein_J_Org_Chem-19-635-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/dc6a4a41ff5e/Beilstein_J_Org_Chem-19-635-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/dbf8b94e533c/Beilstein_J_Org_Chem-19-635-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/e0caf01737c2/Beilstein_J_Org_Chem-19-635-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/db03da975f2a/Beilstein_J_Org_Chem-19-635-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/79ecf523d156/Beilstein_J_Org_Chem-19-635-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/e2e65812133a/Beilstein_J_Org_Chem-19-635-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/86ec41302cf9/Beilstein_J_Org_Chem-19-635-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/90878d60737a/Beilstein_J_Org_Chem-19-635-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/dc6a4a41ff5e/Beilstein_J_Org_Chem-19-635-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/dbf8b94e533c/Beilstein_J_Org_Chem-19-635-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/e0caf01737c2/Beilstein_J_Org_Chem-19-635-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4af1/10186267/db03da975f2a/Beilstein_J_Org_Chem-19-635-g008.jpg

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3
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Carbohydr Polym. 2021 Jan 1;251:116871. doi: 10.1016/j.carbpol.2020.116871. Epub 2020 Aug 10.
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5
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6
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7
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