Denagamage Sachira, Morton Mitchell P, Hudson Nyomi V, Nandy Anirvan S
Department of Neuroscience, Yale University, New Haven, CT 06510.
Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510.
bioRxiv. 2024 Apr 25:2023.05.01.539001. doi: 10.1101/2023.05.01.539001.
Our eyes are in constant motion, yet we perceive the visual world as stable. Predictive remapping of receptive fields is thought to be one of the critical mechanisms for enforcing perceptual stability during eye movements. While receptive field remapping has been identified in several cortical areas, the spatiotemporal dynamics of remapping, and its consequences on the tuning properties of neurons, remain poorly understood. Here, we tracked remapping receptive fields in hundreds of neurons from visual Area V2 while subjects performed a cued saccade task. We found that remapping was far more widespread in Area V2 than previously reported and can be found in neurons from all recorded cortical layers and cell types. Surprisingly, neurons undergoing remapping exhibit sensitivity to two punctate locations in visual space. Furthermore, we found that feature selectivity is not only maintained during remapping but transiently increases due to untuned suppression. Taken together, these results shed light on the spatiotemporal dynamics of remapping and its ubiquitous prevalence in the early visual cortex, and force us to revise current models of perceptual stability.
我们的眼睛在不断运动，但我们却将视觉世界感知为稳定的。感受野的预测性重映射被认为是在眼球运动期间维持感知稳定性的关键机制之一。虽然在几个皮质区域已发现感受野重映射，但重映射的时空动态及其对神经元调谐特性的影响仍知之甚少。在这里，当受试者执行线索化扫视任务时，我们追踪了来自视觉V2区数百个神经元的重映射感受野。我们发现，重映射在V2区比先前报道的更为广泛，并且在所有记录的皮质层和细胞类型的神经元中都能发现。令人惊讶的是，经历重映射的神经元对视觉空间中的两个点状位置表现出敏感性。此外，我们发现特征选择性不仅在重映射期间得以维持，而且由于非调谐抑制而短暂增加。综上所述，这些结果揭示了重映射的时空动态及其在早期视觉皮层中普遍存在的情况，并迫使我们修正当前的感知稳定性模型。
