Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China.
Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China.
Environ Toxicol Pharmacol. 2023 Jun;100:104150. doi: 10.1016/j.etap.2023.104150. Epub 2023 May 17.
This study evaluated the effects of BTEX exposure on oxidative stress; it analyzed the correlation between oxidative stress and peripheral blood counts and estimated the benchmark dose (BMD) of BTEX compounds. This study recruited 247 exposed workers and 256 controls; physical examination data were collected and serum oxidative stress levels were measured. Relationships between BTEX exposure and biomarkers were analyzed using Mann-Whitney U, generalized linear model, and chi-square trend tests. Environmental Protection Agency Benchmark Dose Software was used to calculate the BMD and lower confidence limit of the BMD (BMDL) for BTEX exposure. The total antioxidant capacity (T-AOC) correlated positively with peripheral blood counts, and negatively with the cumulative exposure dose. On using T-AOC as the outcome variable, the estimated BMD and BMDL for BTEX exposure were 3.57 mg/m and 2.20 mg/m, respectively. Based on T-AOC, the calculated occupational exposure limit of BTEX was 0.055 mg/m.
本研究评估了 BTEX 暴露对氧化应激的影响；分析了氧化应激与外周血计数之间的相关性，并估计了 BTEX 化合物的基准剂量 (BMD)。本研究招募了 247 名暴露工人和 256 名对照；收集了体检数据并测量了血清氧化应激水平。使用 Mann-Whitney U、广义线性模型和卡方趋势检验分析了 BTEX 暴露与生物标志物之间的关系。使用美国环境保护署基准剂量软件计算了 BTEX 暴露的 BMD 和 BMD 的置信下限 (BMDL)。总抗氧化能力 (T-AOC) 与外周血计数呈正相关，与累积暴露剂量呈负相关。当使用 T-AOC 作为因变量时，BTEX 暴露的估计 BMD 和 BMDL 分别为 3.57mg/m 和 2.20mg/m。基于 T-AOC，计算出的 BTEX 职业暴露限值为 0.055mg/m。
