利用排阻色谱和化学蛋白质组学发现扰动蛋白质复合物的化学探针。
Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics.
机构信息
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
出版信息
Mol Cell. 2023 May 18;83(10):1544-1546. doi: 10.1016/j.molcel.2023.04.028.
PMID:37207621
Abstract
Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al. develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.
摘要
大多数人类蛋白质缺乏小分子配体，这使得这些蛋白质“不可成药”。在本期《分子细胞》中，Lazear 等人开发了一种新的化学蛋白质组学筛选平台，并发现了针对以前不可成药的蛋白质复合物的新化学探针。
Zotero 插件