Li Shuangjiang, Fan Ruicheng, Wang Yuekai, He Kunqian, Xu Jinhe, Li Hongli
Chongqing Key Laboratory of Neurobiology, Department of Teaching Experiment Center, College of Basic Medicine, Army Medical University, Chongqing, China.
Battalion, College of Basic Medicine, Army Medical University, Chongqing, China.
Front Pharmacol. 2024 Feb 15;15:1352377. doi: 10.3389/fphar.2024.1352377. eCollection 2024.
Low selectivity and tumor drug resistance are the main hinderances to conventional radiotherapy and chemotherapy against tumor. Ion interference therapy is an innovative anti-tumor strategy that has been recently reported to induce metabolic disorders and inhibit proliferation of tumor cells by reordering bioactive ions within the tumor cells. Calcium cation (Ca) are indispensable for all physiological activities of cells. In particular, calcium overload, characterized by the abnormal intracellular Ca accumulation, causes irreversible cell death. Consequently, calcium overload-based ion interference therapy has the potential to overcome resistance to traditional tumor treatment strategies and holds promise for clinical application. In this review, we 1) Summed up the current strategies employed in this therapy; 2) Described the outcome of tumor cell death resulting from this therapy; 3) Discussed its potential application in synergistic therapy with immunotherapy.
低选择性和肿瘤耐药性是传统放疗和化疗治疗肿瘤的主要障碍。离子干扰疗法是一种创新的抗肿瘤策略，最近有报道称，它可通过重新排列肿瘤细胞内的生物活性离子来诱导代谢紊乱并抑制肿瘤细胞增殖。钙阳离子（Ca）对细胞的所有生理活动都是不可或缺的。特别是，以细胞内Ca异常积累为特征的钙超载会导致不可逆的细胞死亡。因此，基于钙超载的离子干扰疗法有潜力克服对传统肿瘤治疗策略的耐药性，并具有临床应用前景。在这篇综述中，我们：1）总结了该疗法目前采用的策略；2）描述了该疗法导致肿瘤细胞死亡的结果；3）讨论了其在与免疫疗法联合治疗中的潜在应用。
