Morley J E, Distiller L A, Epstein S, Katz M, Gold C, Sagel J, Kaye G, Pokroy M, Kalk J
Horm Metab Res. 1979 Jan;11(1):68-72. doi: 10.1055/s-0028-1092683.
Twelve female patients undergoing intermittent hemodialysis (HD) and 5 females posttransplantation (PT) were studied. All the HD patients had menstrual disturbances and 5 had galactorrhea. The mean basal LH level was significantly elevated (p less than .05) in patients on HD compared to normal controls, but the mean LH response to luteinizing hormone releasing hormone (LRH) was not significantly different from the control group. Mean basal FSH and the FSH response to LRH was normal. In the PT pateints the LH response to LRH was significantly greater at 120 min when compared to normal females. In the HD group the serum 17B estradiol, progesterone and testosterone levels were significantly lower than in the controls but in the PT group only testosterone levels were significantly lower. These results differ from those previously found in uremic males. Elevated prolactin levels were found in the patients on hemodialysis and correlated well with the presence of galactorrhea. These was no correlation between the elevated prolactin levels and amenorrhea in the patients on hemodialysis but one PT patient with amenorrhea had elevated prolactin levels.
对12名接受间歇性血液透析（HD）的女性患者和5名移植后（PT）的女性进行了研究。所有血液透析患者均有月经紊乱，5例有溢乳。与正常对照组相比，血液透析患者的平均基础促黄体生成素（LH）水平显著升高（p<0.05），但LH对促黄体生成素释放激素（LRH）的反应与对照组无显著差异。平均基础促卵泡生成素（FSH）及FSH对LRH的反应正常。与正常女性相比，移植后患者在120分钟时对LRH的LH反应显著增强。血液透析组的血清17β雌二醇、孕酮和睾酮水平显著低于对照组，但移植后组仅睾酮水平显著降低。这些结果与先前在尿毒症男性中发现的结果不同。血液透析患者中发现催乳素水平升高，且与溢乳情况密切相关。血液透析患者中催乳素水平升高与闭经之间无相关性，但1例移植后闭经患者催乳素水平升高。
