McKechnie N M, Al-Mahdawi S, Dutton G, Forrester J V
Exp Eye Res. 1986 May;42(5):479-87. doi: 10.1016/0014-4835(86)90007-2.
Retinal S antigen, a uveitogenic protein implicated in several forms of clinical and experimental uveoretinitis, has been localized by immunoelectron microscopy in the human photoreceptor outer segment using a protein A-gold technique and anti-bovine retinal S antigen serum. The protein was predominantly located to the proximal portion of the rod outer segment and appeared to be distributed on the disc membrane but not on the plasma membrane. No immunoreactive product was detected in cone outer segments or in any other retinal structure. These findings are discussed in relation to the physiological function of S antigen and its role in initiation of posterior uveitis.
视网膜S抗原是一种与多种临床和实验性葡萄膜视网膜炎相关的致葡萄膜炎蛋白，利用蛋白A-金技术和抗牛视网膜S抗原血清，通过免疫电子显微镜已将其定位在人光感受器外段。该蛋白主要定位于视杆外段的近端部分，似乎分布在盘膜上而非质膜上。在视锥外段或任何其他视网膜结构中均未检测到免疫反应产物。结合S抗原的生理功能及其在后部葡萄膜炎发病中的作用对这些发现进行了讨论。
