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移植肿瘤肾脏病学:更新。

Transplant Onconephrology: An Update.

机构信息

Division of Nephrology, University of Washington, Seattle, WA; Division of Nephrology, Seattle Children's Hospital, Seattle, WA.

Fred Hutchinson Cancer Center, Seattle, WA.

出版信息

Semin Nephrol. 2022 Nov;42(6):151348. doi: 10.1016/j.semnephrol.2023.151348. Epub 2023 May 18.

DOI:10.1016/j.semnephrol.2023.151348
PMID:37209580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10330527/
Abstract

Transplant onconephrology is a growing specialty focused on the health care of kidney transplant recipients with cancer. Given the complexities associated with the care of transplant patients, along with the advent of novel cancer therapies such as immune checkpoint inhibitors and chimeric antigen-receptor T cells, there is a dire need for the subspecialty of transplant onconephrology. The management of cancer in the setting of kidney transplantation is best accomplished by a multidisciplinary team, including transplant nephrologists, oncologists, and patients. This review addresses the current state and future opportunities for transplant onconephrology, including the roles of the multidisciplinary team, and related scientific and clinical knowledge.

摘要

移植肿瘤肾脏病学是一个不断发展的专业领域,专注于癌症肾移植受者的医疗保健。考虑到移植患者护理的复杂性,以及免疫检查点抑制剂和嵌合抗原受体 T 细胞等新型癌症治疗方法的出现,移植肿瘤肾脏病学亚专业的需求非常迫切。多学科团队(包括移植肾脏病学家、肿瘤学家和患者)最适合管理肾移植患者中的癌症。这篇综述探讨了移植肿瘤肾脏病学的现状和未来机遇,包括多学科团队的作用以及相关的科学和临床知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/4a775e24341f/nihms-1904411-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/ec03327895d6/nihms-1904411-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/8d0eee520c75/nihms-1904411-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/4a775e24341f/nihms-1904411-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/ec03327895d6/nihms-1904411-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/8d0eee520c75/nihms-1904411-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31cd/10330527/4a775e24341f/nihms-1904411-f0003.jpg

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Nivolumab + Tacrolimus + Prednisone ± Ipilimumab for Kidney Transplant Recipients With Advanced Cutaneous Cancers.纳武单抗+他克莫司+泼尼松±伊匹单抗用于患有晚期皮肤癌的肾移植受者。
J Clin Oncol. 2024 Mar 20;42(9):1011-1020. doi: 10.1200/JCO.23.01497. Epub 2024 Jan 22.
2
Relapsed or refractory large B-cell lymphoma after chimeric antigen receptor T-cell therapy: Current challenges and therapeutic options.嵌合抗原受体T细胞疗法后复发或难治性大B细胞淋巴瘤:当前挑战与治疗选择
Br J Haematol. 2023 Apr;201(1):15-24. doi: 10.1111/bjh.18656. Epub 2023 Jan 29.
3
CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
嵌合抗原受体 T 细胞(CAR-T)疗法治疗实体器官移植受者:病例报告和系统评价。
Bone Marrow Transplant. 2023 Apr;58(4):353-359. doi: 10.1038/s41409-022-01907-z. Epub 2022 Dec 27.
4
Epidemiology of Renal Cell Carcinoma: 2022 Update.肾细胞癌的流行病学:2022 年更新。
Eur Urol. 2022 Nov;82(5):529-542. doi: 10.1016/j.eururo.2022.08.019. Epub 2022 Sep 10.
5
Immune checkpoint inhibitors in kidney transplant recipients: a multicentre, single-arm, phase 1 study.肾移植受者的免疫检查点抑制剂:一项多中心、单臂、1 期研究。
Lancet Oncol. 2022 Aug;23(8):1078-1086. doi: 10.1016/S1470-2045(22)00368-0. Epub 2022 Jul 6.
6
CAR T-cell Infusion Following Checkpoint Inhibition Can Induce Remission in Chemorefractory Post-transplant Lymphoproliferative Disorder of the CNS.检查点抑制后进行嵌合抗原受体T细胞输注可诱导中枢神经系统化疗难治性移植后淋巴细胞增生性疾病缓解。
Hemasphere. 2022 Jun 17;6(7):e733. doi: 10.1097/HS9.0000000000000733. eCollection 2022 Jul.
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J Palliat Med. 2022 Jul;25(7):1136-1142. doi: 10.1089/jpm.2022.0013. Epub 2022 Mar 11.
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