Section of Nephrology, School of Medicine, Yale University, New Haven, Connecticut.
Section of Nephrology, School of Medicine, Yale University, New Haven, Connecticut.
Am J Kidney Dis. 2023 Dec;82(6):743-761. doi: 10.1053/j.ajkd.2023.04.014. Epub 2023 Oct 17.
Onconephrology focuses on management of kidney disease in cancer, which manifests itself in a variety of clinical syndromes, including acute kidney injury, chronic kidney disease, hypertension, proteinuria, and electrolyte disorders. Many of these syndromes result from cancer treatments including chemotherapy, immunotherapy, chimeric antigen receptor T cells, and stem cell transplant. Others are due to kidney-specific effects of the cancer, as seen with monoclonal gammopathy or glomerular diseases associated with malignancy. Further, cancer risk itself is heightened in patients with kidney disease, particularly kidney transplant recipients, and their care requires specific considerations. In this installment of AJKD's Core Curriculum in Nephrology, we review these and other core concepts in onconephrology, using a case-based approach to highlight clinical decision making.
Onconephrology 专注于癌症相关肾脏疾病的管理，其表现为多种临床综合征，包括急性肾损伤、慢性肾脏病、高血压、蛋白尿和电解质紊乱。这些综合征中的许多是由癌症治疗引起的，包括化疗、免疫疗法、嵌合抗原受体 T 细胞和干细胞移植。其他则是由于癌症对肾脏的特异性影响，如单克隆丙种球蛋白病或与恶性肿瘤相关的肾小球疾病。此外，患有肾脏疾病的患者（尤其是肾移植受者）癌症风险增加，他们的治疗需要特别考虑。在本期 AJKD 的肾脏病学核心课程中，我们将使用基于案例的方法来突出临床决策，复习这些和其他 Onconephrology 中的核心概念。
