Vercelloni M, Cogo R, Albertini A, Granata M, Rosaschino F
J Int Med Res. 1986;14(3):131-6. doi: 10.1177/030006058601400303.
Sixty patients affected by chronic obstructive lung disease (COLD) in relapse were treated with erythromycin and aminophylline. The patients were divided into three groups: Group A received 2 g erythromycin and 1200 mg aminophylline daily, and Group B and C received 2 g erythromycin with respectively 800 mg and 600 mg of aminophylline daily, administered as two oral doses in each case. On day 5 of therapy, we chromatographically evaluated aminophylline in a serum sample taken two hours after morning drug administration which corresponds to the peak plasma level. We also evaluated certain biohumoral, microbiological, radiological and electrocardiographic parameters both before and after therapy. Statistical analysis of the data was performed by the Student's t test. Our data confirm that 600-800 mg oral aminophylline administered simultaneously with erythromycin induce an improvement in the respiratory function of patients with relapsed COLD without elevating blood aminophylline levels and without side-effects.
60例慢性阻塞性肺疾病（COLD）复发患者接受了红霉素和氨茶碱治疗。患者被分为三组：A组每天接受2g红霉素和1200mg氨茶碱，B组和C组每天接受2g红霉素，分别加用800mg和600mg氨茶碱，均分两次口服给药。在治疗第5天，我们对早晨服药两小时后采集的血清样本中的氨茶碱进行了色谱分析评估，此时对应血浆峰浓度。我们还在治疗前后评估了某些生物体液、微生物学、放射学和心电图参数。数据采用Student's t检验进行统计分析。我们的数据证实，与红霉素同时口服600 - 800mg氨茶碱可改善COLD复发患者的呼吸功能，且不会提高血氨茶碱水平，也无副作用。
