饮食抗氧化能力与缺血性脑卒中患者颈动脉粥样硬化狭窄的关系。
Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke.
机构信息
Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China.
Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, China; Department of Neurology, Affiliated Jinling Hospital, Nanjing Medical University, Nanjing, China.
出版信息
J Stroke Cerebrovasc Dis. 2023 Aug;32(8):107148. doi: 10.1016/j.jstrokecerebrovasdis.2023.107148. Epub 2023 May 20.
BACKGROUND AND PURPOSE
The aim of this study was to evaluate the relationship between dietary total antioxidant capacity (DTAC) and atherosclerotic carotid stenosis in patients with ischemic stroke.
METHODS
Patients with acute ischemic stroke were consecutively enrolled. Daily food consumption was estimated by a semi-quantitative food frequency questionnaire (FFQ). DTAC was calculated based on classified food intake. Antioxidant potential value was measured by ferric-reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) methods. Evaluation of carotid artery stenosis was based on computed tomography angiography (CTA). Logistic regression was used to assess the relationship between DTAC and degree of carotid stenosis.
RESULTS
Of the 608 enrolled, 232 patients (38.2%) had moderate or severe carotid stenosis. After adjusting for major confounding factors, FRAP (OR =0.640; 95% CI: 0.410-0.998; P =0.049) and ORAC (OR =0.625; 95% CI: 0.400-0.976; P =0.039) were associated with lower degree of carotid artery stenosis (third vs first tertile). Spearman analysis indicated that FRAP (r =-0.121, P =0.003) and ORAC (r =-0.147, P <0.001) were correlated with degree of carotid stenosis.
CONCLUSIONS
DTAC may influence the initiation and development of atherosclerosis, and, therefore, the risk of ischemic stroke.
背景与目的
本研究旨在评估饮食总抗氧化能力（DTAC）与缺血性脑卒中患者颈动脉粥样硬化狭窄之间的关系。
方法
连续纳入急性缺血性脑卒中患者。通过半定量食物频率问卷（FFQ）评估每日食物摄入量。根据分类食物摄入量计算 DTAC。抗氧化能力值通过铁还原抗氧化能力（FRAP）和氧自由基吸收能力（ORAC）方法测量。颈动脉狭窄评估基于计算机断层血管造影（CTA）。使用逻辑回归评估 DTAC 与颈动脉狭窄程度之间的关系。
结果
在纳入的 608 名患者中，232 名（38.2%）患者存在中度或重度颈动脉狭窄。在调整了主要混杂因素后，FRAP（OR=0.640；95%CI：0.410-0.998；P=0.049）和 ORAC（OR=0.625；95%CI：0.400-0.976；P=0.039）与较低程度的颈动脉狭窄（第三与第一 tertile）相关。Spearman 分析表明，FRAP（r=-0.121，P=0.003）和 ORAC（r=-0.147，P<0.001）与颈动脉狭窄程度相关。
结论
DTAC 可能影响动脉粥样硬化的发生和发展，从而影响缺血性脑卒中的风险。
Zotero 插件