Department of Obstetrics and Gynecology, Bursa Yuksek Ihtisas Educational and Research Hospital, Bursa, Turkey.
Department of Obstetrics and Gynecology, Uludag University, Bursa, Turkey.
J Obstet Gynaecol Res. 2023 Jul;49(7):1729-1735. doi: 10.1111/jog.15666. Epub 2023 May 21.
Hyperemesis gravidarum (HG) is one of the most common serious diseases in early pregnancy. This study aimed to investigate the clinical significance of hemoglobin, albumin, lymphocyte, and platelet (HALP) score and systemic immune inflammation (SII) index in the presence and severity of HG.
This retrospective case-control study was conducted in a training and educational university hospital between January 2019 and July 2022. A total of 521 pregnant women, of whom 360 were diagnosed with HG at 6-14 weeks of gestation and 161 were low-risk pregnancies, were included in the study. Patients' demographic characteristics and laboratory parameters were recorded. Patients with HG were divided into three categories: mild (n = 160), moderate (n = 116), and severe (n = 84), according to disease severity. The modified PUQE scoring was used to determine the severity of HG.
The mean age of the patients was 27.6 (16-40) years. We divided the pregnant women into the control group and HG group. The HALP score was significantly lower in the HG group (average, 2.8 ± 1.3), whereas the SII index was found to be significantly higher (average, 895.8 ± 458.1). A negative correlation was found between the increase in the severity of HG and HALP score. The HALP score was the lower in severe HG (mean, 2.16 ± 0.81) and was significantly different from other HG categories (p < 0.01). Moreover, a positive correlation was noted between increased HG severity and SII index levels. The SII index was higher in the severe HG group and was significantly different from the others (1001.2 ± 437.2) (p < 0.01).
The HALP score and SII index can be useful, cost-effective, and easily accessible objective biomarkers to predict the presence and severity of HG.
妊娠剧吐（HG）是妊娠早期最常见的严重疾病之一。本研究旨在探讨血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分和全身免疫炎症（SII）指数在 HG 的存在和严重程度中的临床意义。
本回顾性病例对照研究于 2019 年 1 月至 2022 年 7 月在一所培训和教育大学医院进行。共纳入 521 名孕妇，其中 360 名在 6-14 周妊娠时被诊断为 HG，161 名孕妇为低危妊娠。记录患者的人口统计学特征和实验室参数。根据疾病严重程度，将 HG 患者分为轻度（n=160）、中度（n=116）和重度（n=84）三组。采用改良的 PUQE 评分来确定 HG 的严重程度。
患者的平均年龄为 27.6（16-40）岁。我们将孕妇分为对照组和 HG 组。HG 组的 HALP 评分明显较低（平均，2.8±1.3），而 SII 指数明显较高（平均，895.8±458.1）。HG 严重程度增加与 HALP 评分呈负相关。严重 HG 的 HALP 评分最低（平均，2.16±0.81），与其他 HG 类别有显著差异（p<0.01）。此外，HG 严重程度增加与 SII 指数水平呈正相关。严重 HG 组的 SII 指数较高，与其他组有显著差异（1001.2±437.2）（p<0.01）。
HALP 评分和 SII 指数可作为预测 HG 存在和严重程度的有用、具有成本效益且易于获得的客观生物标志物。
