Worgul B V, Merriam G R
Invest Ophthalmol Vis Sci. 1979 Apr;18(4):401-8.
Intraocular inflammation induced by an intravitreal injection of Shigella endotoxin into the rat eye produces early changes in the number of dividing cells of the lens epithelium and affects the organization of the meridional rows. A depression in mitotic activity in the germinative zone is observed during the first 24 hr after injection. At 48 hr, despite the continued mitotic inhibition in the germinative zone, an increase in cell division occurs in the central zone. By 72 hr, the germinative zone mitosis reappears and exceeds control values, whereas the central zone mitotic activity returns to normal. At that time mitotic figures are found in the transitional zone. Disorganization of the meridional rows is seen as early as 12 hr after injection (the first time period observed) and reaches a peak by 48 hr. During the next 5 days, however, the severity of the disorganization diminishes. By the seventh day the rows appear, for the most part, fully recovered, and the mitotic activity reaches normal or near-normal levels in all regions. The details of these observations and their possible relationship to inflammatory cataracta complicata are discussed.
向大鼠眼玻璃体内注射志贺氏菌内毒素所诱导的眼内炎症，会使晶状体上皮分裂细胞数量出现早期变化，并影响子午线排列的组织结构。注射后最初24小时内，生发区有丝分裂活性降低。48小时时，尽管生发区仍存在有丝分裂抑制，但中央区细胞分裂增加。到72小时时，生发区有丝分裂重新出现并超过对照值，而中央区有丝分裂活性恢复正常。此时在过渡区可见有丝分裂象。子午线排列紊乱最早在注射后12小时（观察的第一个时间段）就可看到，并在48小时达到高峰。然而，在接下来的5天里，紊乱的严重程度逐渐减轻。到第7天时，这些排列在很大程度上似乎已完全恢复，所有区域的有丝分裂活性都达到正常或接近正常水平。文中讨论了这些观察结果的细节及其与复杂性炎症性白内障可能的关系。
