van Berkel Annemaria C, Schiphof Dieuwke, Waarsing Jan H, Runhaar Jos, van Ochten John M, Bindels Patrick J E, Bierma-Zeinstra Sita M A
Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Osteoarthr Cartil Open. 2023 Apr 14;5(3):100363. doi: 10.1016/j.ocarto.2023.100363. eCollection 2023 Sep.
To explore the prevalence of nocturnal pain and fatigue in participants with hip symptoms suspected to be early osteoarthritis (OA) and to test the mediating effect of nocturnal pain on the association between hip OA pain and fatigue.
We included participants with hip pain but no knee pain at baseline, from the Cohort Hip and Cohort Knee (CHECK)-study. Severity of hip OA pain was determined using the Numeric-Rating-Scale-pain-score last week. Fatigue was assessed using the SF-36 Fatigue subscale. Nocturnal pain was determined using the WOMAC-question: "How much pain have you experienced in the last 48 h at night while in bed?". Hip OA pain, nocturnal pain and fatigue were measured repeatedly during 10-year follow-up. Path analysis were used per time point to determine the direct effect of OA pain on fatigue and the indirect effect through nocturnal pain.
In 170 participants (female: 76%; mean age: 55.7 years; mean BMI: 25.5 kg/m) the prevalence of nocturnal pain varied between 22 and 35% and the prevalence of fatigue ranged between 14 and 18%. Hip OA pain was associated with nocturnal pain and fatigue. The direct effect of hip OA pain on fatigue was significant at all-time points. No significant mediating effect of nocturnal pain was found.
In this cohort of participants suspected to have early hip OA, the prevalence of fatigue remained stable and the prevalence of nocturnal pain decreased slightly over 10-year follow-up. We did not find a mediating effect of nocturnal pain in the pathway between hip OA pain and fatigue.
探讨疑似早期骨关节炎（OA）的髋关节症状参与者夜间疼痛和疲劳的患病率，并检验夜间疼痛对髋关节OA疼痛与疲劳之间关联的中介作用。
我们纳入了队列髋关节和队列膝关节（CHECK）研究中基线时存在髋关节疼痛但无膝关节疼痛的参与者。使用上周的数字评分量表疼痛评分来确定髋关节OA疼痛的严重程度。使用SF-36疲劳分量表评估疲劳情况。通过WOMAC问题“您在床上时，过去48小时夜间经历了多少疼痛？”来确定夜间疼痛。在10年随访期间重复测量髋关节OA疼痛、夜间疼痛和疲劳。在每个时间点使用路径分析来确定OA疼痛对疲劳的直接作用以及通过夜间疼痛的间接作用。
在170名参与者中（女性：76%；平均年龄：55.7岁；平均BMI：25.5kg/m），夜间疼痛的患病率在22%至35%之间，疲劳的患病率在14%至18%之间。髋关节OA疼痛与夜间疼痛和疲劳相关。髋关节OA疼痛对疲劳的直接作用在所有时间点均显著。未发现夜间疼痛有显著的中介作用。
在这个疑似患有早期髋关节OA的参与者队列中，在10年随访期间，疲劳的患病率保持稳定，夜间疼痛的患病率略有下降。我们未发现夜间疼痛在髋关节OA疼痛与疲劳之间的路径中有中介作用。
