Meyer Henry, Mamani Sandra, Li Zhi, Shi Lingyan, Alfano Robert
The City College of the City University of New York.
University of California San Diego.
Res Sq. 2023 May 10:rs.3.rs-2829849. doi: 10.21203/rs.3.rs-2829849/v1.
The Optical Kerr Effect was demonstrated for the first time as a new optical biopsy method to detect normal and grades of cancer of human breast tissues. The technique works by temporally tracking the various electronic and molecular processes that give rise to the nonlinear index of refraction (n). The rate at which these processes populate and dissipate varies depending on the internal properties of the sample. It is shown here that in tissues, the variances in the ultrafast plasma Kerr responses that relates to the dielectric relaxation can be used as a biomarker for cancer. The relaxation of this response changes significantly between healthy and different grades of triple negative breast cancer tissues. This change can be attributed to a doubling or tripling of the tissue's conductivity depending on the cancer grade.
光学克尔效应首次被证明是一种用于检测人类乳腺组织正常情况和癌症分级的新型光学活检方法。该技术通过时间跟踪产生非线性折射率（n）的各种电子和分子过程来工作。这些过程的填充和消散速率取决于样品的内部特性。本文表明，在组织中，与介电弛豫相关的超快等离子体克尔响应的变化可以用作癌症的生物标志物。这种响应的弛豫在健康组织和不同分级的三阴性乳腺癌组织之间有显著变化。这种变化可归因于根据癌症分级，组织电导率增加一倍或两倍。
