Konečná Andrea, Rotunno Enzo, Grillo Vincenzo, García de Abajo F Javier, Vanacore Giovanni Maria
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Castelldefels, Barcelona 08860, Spain.
Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.
ACS Photonics. 2023 Apr 19;10(5):1463-1472. doi: 10.1021/acsphotonics.3c00047. eCollection 2023 May 17.
Single-pixel imaging, originally developed in light optics, facilitates fast three-dimensional sample reconstruction as well as probing with light wavelengths undetectable by conventional multi-pixel detectors. However, the spatial resolution of optics-based single-pixel microscopy is limited by diffraction to hundreds of nanometers. Here, we propose an implementation of single-pixel imaging relying on attainable modifications of currently available ultrafast electron microscopes in which optically modulated electrons are used instead of photons to achieve subnanometer spatially and temporally resolved single-pixel imaging. We simulate electron beam profiles generated by interaction with the optical field produced by an externally programmable spatial light modulator and demonstrate the feasibility of the method by showing that the sample image and its temporal evolution can be reconstructed using realistic imperfect illumination patterns. Electron single-pixel imaging holds strong potential for application in low-dose probing of beam-sensitive biological and molecular samples, including rapid screening during in situ experiments.
单像素成像最初是在光学领域开发的，它有助于快速进行三维样本重建，以及利用传统多像素探测器无法检测到的光波长进行探测。然而，基于光学的单像素显微镜的空间分辨率受衍射限制，只能达到数百纳米。在此，我们提出一种单像素成像的实现方法，该方法依赖于对现有超快电子显微镜进行可行的改进，其中使用光学调制电子而非光子来实现亚纳米级的空间和时间分辨单像素成像。我们模拟了与外部可编程空间光调制器产生的光场相互作用所产生的电子束轮廓，并通过表明使用实际的非理想照明模式可以重建样本图像及其时间演化，证明了该方法的可行性。电子单像素成像在对束敏感的生物和分子样本进行低剂量探测方面具有很强的应用潜力，包括在原位实验期间进行快速筛选。
