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膝关节血友病性关节病:外科医生的噩梦。

Haemophilic arthropathy of the knee: a surgeon's nightmare.

作者信息

Khan Mohammad Jesan, Asif Naiyer, Siddiqui Yasir Salam, Aziz Mohd Hadi, Raza Ariz, Alam Noor

机构信息

Department of Orthopaedic Surgery, JNMCH, AMU Aligarh, Uttar Pradesh, India.

Department of Orthopaedic Surgery, Hamdard Institute of Medical Sciences & Research (HIMSR) New Delhi, India.

出版信息

Int J Burns Trauma. 2023 Apr 15;13(2):89-93. eCollection 2023.

PMID:37215510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10195220/
Abstract

Surgical management of knee synovitis secondary to mild haemophilia, without any significant previous medical history and an adverse family history of haematological disorders, is arduous. Due to its rare occurrence, the diagnosis is often delayed or sometimes missed, leading to the grave and often lethal consequences in intraoperative and postoperative periods. Hardly isolated knee arthropathy due to mild haemophilia has been reported in the available literature. In this report, we present the management of a case of a 16-year-old male with isolated knee synovitis with undiagnosed mild haemophilia, who came to us with the first episode of knee bleeding. We elucidate the signs and symptoms, investigations, surgical management, and difficulties faced, especially during the postoperative period. This case report is presented to enhance awareness of the existence of this disorder and its management to prevent postoperative complications.

摘要

对于继发于轻度血友病的膝关节滑膜炎患者,若无任何重要既往病史及血液系统疾病家族史,其外科治疗颇具难度。由于该病罕见,诊断常被延误,有时甚至漏诊,从而在术中和术后导致严重且往往致命的后果。现有文献中鲜有关于轻度血友病所致单纯膝关节病的报道。在本报告中,我们介绍了一例16岁男性患者的治疗情况,该患者患有未确诊的轻度血友病且伴有单纯膝关节滑膜炎,因首次膝关节出血前来就诊。我们阐述了其症状体征、检查、外科治疗以及所面临的困难,尤其是术后的困难。本病例报告旨在提高对该疾病存在及其治疗的认识,以预防术后并发症。

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Haemophilic arthropathy of the knee: a surgeon's nightmare.膝关节血友病性关节病:外科医生的噩梦。
Int J Burns Trauma. 2023 Apr 15;13(2):89-93. eCollection 2023.
2
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本文引用的文献

1
WFH Guidelines for the Management of Hemophilia, 3rd edition.《血友病管理的居家指南》第三版
Haemophilia. 2020 Aug;26 Suppl 6:1-158. doi: 10.1111/hae.14046. Epub 2020 Aug 3.
2
Dental management of a patient with incidentally detected hemophilia: Report of a clinical case.偶然发现的血友病患者的牙科治疗:一例临床病例报告。
J Indian Soc Periodontol. 2019 May-Jun;23(3):281-283. doi: 10.4103/jisp.jisp_461_18.
3
Haemophilia and joint disease: pathophysiology, evaluation, and management.血友病与关节疾病:病理生理学、评估及管理
J Comorb. 2011 Dec 27;1:51-59. doi: 10.15256/joc.2011.1.2. eCollection 2011.
4
Imaging of haemophilic arthropathy in growing joints: pitfalls in ultrasound and MRI.生长关节中血友病性关节病的影像学:超声和 MRI 的陷阱。
Haemophilia. 2017 Sep;23(5):660-672. doi: 10.1111/hae.13249. Epub 2017 Jun 2.
5
Orthopedic disorders of the knee in hemophilia: A current concept review.血友病患者膝关节的骨科疾病:当前概念综述
World J Orthop. 2016 Jun 18;7(6):370-5. doi: 10.5312/wjo.v7.i6.370.
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Musculo-skeletal manifestations of haemophilia.血友病的肌肉骨骼表现
Blood Rev. 2016 Sep;30(5):401-9. doi: 10.1016/j.blre.2016.04.008. Epub 2016 May 4.
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Mild haemophilia: a disease with many faces and many unexpected pitfalls.轻度血友病:一种具有多种表现形式和许多意外陷阱的疾病。
Haemophilia. 2010 Jul;16 Suppl 5:100-6. doi: 10.1111/j.1365-2516.2010.02306.x.
8
Mild hemophilia A.轻度血友病 A。
J Thromb Haemost. 2010 Mar;8(3):421-32. doi: 10.1111/j.1538-7836.2009.03717.x. Epub 2009 Dec 7.
9
Musculoskeletal complications of hemophilia.血友病的肌肉骨骼并发症。
HSS J. 2010 Feb;6(1):37-42. doi: 10.1007/s11420-009-9140-9. Epub 2009 Nov 17.
10
Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV.英国未感染艾滋病毒的甲型或乙型血友病患者的死亡率、预期寿命和死因
Blood. 2007 Aug 1;110(3):815-25. doi: 10.1182/blood-2006-10-050435. Epub 2007 Apr 19.