Seva Juan, Sanes José Manuel, Bueno Juan Manuel, De Jódar Carlos, Soler Marta, Bayón Alejandro, Párraga-Ros Ester
Department of Anatomy and Comparative Pathology, Veterinary Teaching Hospital University of Murcia Murcia Spain.
Optics Laboratory, Center for Research in Optics and Nanophysics University of Murcia Murcia Spain.
Clin Case Rep. 2023 May 18;11(5):e7159. doi: 10.1002/ccr3.7159. eCollection 2023 May.
This study describes a case of a 20-day-old male fighting bull with bilateral clinical anophthalmia and brachygnathia superior whose dam was 12.5 years old and was mistakenly dewormed with ivermectin intramuscularly in the first third of gestation in a livestock farm. A macroscopic examination of the carcass was performed, with a special focus on the ocular components. Eyeball remains were found in both orbits and a histopathological examination was performed on them. Antibodies by serological study against bovine herpes virus-1, respiratory syncytial virus and bovine viral diarrhea virus for both the cow and the calf were not detected. The calf had small orbits and inside them a white and brown mass of soft consistency. Microscopically, abundant muscular and adipose tissue was observed, alongside nervous structures and vestiges of ocular structures with stratified epithelium and abundant connective tissue with glands. No evidence that this congenital bilateral anophthalmia had infectious or hereditary origin was found. By contrast, the malformation could be related to the treatment with ivermectin during the first month of gestation.
本研究描述了一例20日龄雄性斗牛犊的病例，该犊牛患有双侧临床无眼畸形和上颌前突，其母系为12.5岁，在一个畜牧场中，于妊娠前三分之一阶段被误用伊维菌素进行了肌肉注射驱虫。对尸体进行了大体检查，特别关注眼部结构。在两个眼眶中均发现了眼球残余，并对其进行了组织病理学检查。通过血清学研究未检测到母牛和犊牛针对牛疱疹病毒1型、呼吸道合胞病毒和牛病毒性腹泻病毒的抗体。犊牛眼眶较小，眶内有一个质地柔软的白色和棕色肿块。显微镜下，观察到大量肌肉和脂肪组织，以及神经结构和带有复层上皮的眼结构遗迹，还有富含腺体的结缔组织。未发现证据表明这种先天性双侧无眼畸形具有感染性或遗传性起源。相比之下，这种畸形可能与妊娠第一个月使用伊维菌素治疗有关。
