Serdengeçti S, Serdengeçti K, Derman U, Berkarda B
Int J Clin Pharmacol Res. 1986;6(2):151-5.
The effects of salmon calcitonin administered 100 IU i.m. daily for 30 consecutive days were evaluated in patients with painful bone metastasis secondary to different types of solid cancer. The results were compared with placebo-receiving patients. In the 22 patients treated with calcitonin a significant reduction ( p less than 0.001) was observed in the severity of bone pain. Significant reductions were also encountered in the serum alkaline phosphatase (p less than 0.02) and urinary hydroxyproline excretion values (p less than 0.05) in calcitonin-treated patients, indicating an inhibition of bone destruction. It is concluded that salmon calcitonin has an important place in the treatment of patients with metastatic bone lesions both as a potent analgesic and as an effective inhibitor of bone destruction.
对不同类型实体癌继发的疼痛性骨转移患者，评估连续30天每日肌肉注射100国际单位鲑鱼降钙素的效果，并与接受安慰剂的患者进行结果比较。在接受降钙素治疗的22例患者中，骨痛严重程度显著降低（p<0.001）。降钙素治疗患者的血清碱性磷酸酶（p<0.02）和尿羟脯氨酸排泄值也显著降低（p<0.05），表明骨破坏受到抑制。结论是，鲑鱼降钙素在转移性骨病变患者的治疗中具有重要地位，既是一种有效的镇痛药，也是一种有效的骨破坏抑制剂。
