Schiraldi G F, Soresi E, Locicero S, Harari S, Scoccia S
Int J Clin Pharmacol Ther Toxicol. 1987 Apr;25(4):229-32.
The analgesic effect of salmon calcitonin (Calcitonina-Sandoz) was evaluated in an open study of thirty-four patients with bone metastases of a lung cancer. Two different administration protocols were used: eighteen subjects received sCT 400 IU/day for three consecutive days, while the remaining sixteen were given sCT 200 IU/day for six consecutive days. In both protocols salmon calcitonin was diluted in saline and infused intravenously in one hour. Bone, visceral and neuritic pain were evaluated by means of Huskisson's visual analog scale and Keele's pain scale. The analgesic efficacy of salmon calcitonin was also evaluated on the basis of daily consumption of analgesic drugs. Salmon calcitonin proved of extreme efficacy in the treatment of intractable pain from advanced malignancy. A higher and earlier analgesic activity was observed with sCT at the 400 IU daily dosage.
在一项针对34例肺癌骨转移患者的开放性研究中，评估了鲑鱼降钙素（Sandoz降钙素）的镇痛效果。使用了两种不同的给药方案：18名受试者连续三天每天接受400 IU的鲑鱼降钙素，而其余16名受试者连续六天每天接受200 IU的鲑鱼降钙素。在两种方案中，鲑鱼降钙素均用生理盐水稀释，并在一小时内静脉输注。通过Huskisson视觉模拟量表和Keele疼痛量表评估骨痛、内脏痛和神经痛。还根据镇痛药的每日消耗量评估鲑鱼降钙素的镇痛效果。鲑鱼降钙素在治疗晚期恶性肿瘤引起的顽固性疼痛方面显示出极高的疗效。每日剂量为400 IU的鲑鱼降钙素观察到更高且更早的镇痛活性。
