Tóth-Kása I, Jancsó G, Bognár A, Husz S, Obál F
Int J Clin Pharmacol Res. 1986;6(2):163-9.
The effects of topical treatment with capsaicin or mustard oil on histamine-induced pruritus, wheal formation and flare response were studied in the human skin. Capsaicin pretreatment resulted in a reversible marked reduction or abolition of the axon reflex flare, but did not influence whealing. Itching was also strongly diminished or even abolished, provided that the flare response was completely blocked. The onset of itching was significantly promoted by pretreatment of the skin with mustard oil, inducing axon reflex vasodilatation. It is concluded that, in addition to the axon reflex flare, capsaicin-sensitive peptide-containing primary afferent neurones are also intimately involved in the mediation of the sensation of itching.
研究了辣椒素或芥子油局部治疗对人体皮肤组胺诱导的瘙痒、风团形成和潮红反应的影响。辣椒素预处理导致轴突反射性潮红明显可逆性减少或消失，但不影响风团形成。只要潮红反应被完全阻断，瘙痒也会显著减轻甚至消失。芥子油预处理皮肤可诱导轴突反射性血管扩张，显著促进瘙痒发作。结论是，除了轴突反射性潮红外，含辣椒素敏感肽的初级传入神经元也密切参与瘙痒感觉的介导。
