Key Laboratory of Tea Science of Ministry of Educatioxn, Changsha, China.
National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha, China.
Crit Rev Food Sci Nutr. 2024;64(25):9333-9352. doi: 10.1080/10408398.2023.2212069. Epub 2023 May 22.
Epigallocatechin gallate (EGCG), a naturally occurring active ingredient unique to tea, has been shown to have neuroprotective potential. There is growing evidence of its potential advantages in the prevention and treatment of neuroinflammation, neurodegenerative diseases, and neurological damage. Neuroimmune communication is an important physiological mechanism in neurological diseases, including immune cell activation and response, cytokine delivery. EGCG shows great neuroprotective potential by modulating signals related to autoimmune response and improving communication between the nervous system and the immune system, effectively reducing the inflammatory state and neurological function. During neuroimmune communication, EGCG promotes the secretion of neurotrophic factors into the repair of damaged neurons, improves intestinal microenvironmental homeostasis, and ameliorates pathological phenotypes through molecular and cellular mechanisms related to the brain-gut axis. Here, we discuss the molecular and cellular mechanisms of inflammatory signaling exchange involving neuroimmune communication. We further emphasize that the neuroprotective role of EGCG is dependent on the modulatory role between immunity and neurology in neurologically related diseases.
没食子儿茶素没食子酸酯 (EGCG) 是一种天然存在的、茶叶中特有的活性成分，具有神经保护作用。越来越多的证据表明，它在预防和治疗神经炎症、神经退行性疾病和神经损伤方面具有潜在优势。神经免疫通讯是包括免疫细胞激活和反应、细胞因子传递等在内的神经疾病中的一种重要生理机制。EGCG 通过调节与自身免疫反应相关的信号，改善神经系统与免疫系统之间的通讯，有效减轻炎症状态和神经功能障碍，从而显示出巨大的神经保护潜力。在神经免疫通讯过程中，EGCG 通过与脑肠轴相关的分子和细胞机制，促进神经营养因子分泌到受损神经元的修复中，改善肠道微环境的稳态，改善病理表型。在这里，我们讨论了涉及神经免疫通讯的炎症信号交换的分子和细胞机制。我们进一步强调，EGCG 的神经保护作用依赖于神经相关疾病中免疫与神经之间的调节作用。
