Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.
Department of Agricultural and Environmental Sciences, College of Agriculture, Tennessee State University, Nashville, TN 37209, USA.
Biomolecules. 2022 Feb 25;12(3):371. doi: 10.3390/biom12030371.
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer's disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities. This report also re-examines the current literature and provides innovative approaches for EGCG to be used as a preventive measure to alleviate AD and other neurodegenerative disorders.
阿尔茨海默病和帕金森病是两种最常见的神经退行性疾病。这些疾病的确切病因尚不清楚；然而，环境、分子和遗传因素在这些疾病的发病机制中起着重要作用。以阿尔茨海默病 (AD) 为典型代表，病理发现包括淀粉样β (Aβ) 肽的聚集、线粒体功能障碍、炎症引起的突触降解、活性氧 (ROS) 升高和脑血管调节失调。本综述强调了表没食子儿茶素没食子酸酯 (EGCG) 的神经炎症和神经保护作用：绿茶的药用成分，一种已知的营养保健品，由于其抗氧化、抗炎和抗衰老能力，在调节 AD 进展方面显示出前景。本报告还重新审查了当前的文献，并为 EGCG 提供了创新的应用方法，作为预防措施来减轻 AD 和其他神经退行性疾病。
