Gerhardsson M, Rosenqvist U, Ahlbom A, Carlson L A
Int J Epidemiol. 1986 Jun;15(2):155-9. doi: 10.1093/ije/15.2.155.
The time relationship between low serum cholesterol and the subsequent development of malignant neoplasms was examined in a case-control study of 100 cases of cancer death and 393 controls. The serum cholesterol levels were followed by repeated blood analysis over a 16-year period. An association between low serum cholesterol and cancer death was found particularly for malignant neoplasms of the large intestine and rectum. This relationship diminished 7-16 years prior to death suggesting that the low serum cholesterol levels were an effect of the cancer in an early stage and not vice versa.
在一项对100例癌症死亡病例和393名对照进行的病例对照研究中，研究了低血清胆固醇与随后发生恶性肿瘤之间的时间关系。在16年的时间里，通过反复血液分析追踪血清胆固醇水平。发现低血清胆固醇与癌症死亡之间存在关联，特别是对于大肠和直肠的恶性肿瘤。这种关系在死亡前7至16年减弱，表明低血清胆固醇水平是癌症早期的一种效应，而非相反。
