O'Rourke J S, Johnson A, Collins P, Duignan J, Bouchier-Hayes D
Department of Surgery, Royal College of Surgeons in Ireland.
Gut. 1992 Jul;33(7):950-3. doi: 10.1136/gut.33.7.950.
A group of 114 Irish patients with primary adenocarcinoma of the large bowel had significantly lower serum cholesterol concentrations than an age and sex matched group drawn from the general population. The hypocholesterolaemiac trait was manifest in male and female patients. Rigorous control procedures established that it was neither an artefact of nutritional compromise nor of preoperative bowel preparatory protocols. The data suggested that the appreciable hypocholesterolaemia observed was not influenced by the pathological stage or degree of differentiation of the tumour.
一组114名患有原发性大肠腺癌的爱尔兰患者，其血清胆固醇浓度显著低于从普通人群中选取的年龄和性别匹配组。低胆固醇血症特征在男性和女性患者中均有体现。严格的对照程序证实，这既不是营养不足的假象，也不是术前肠道准备方案造成的。数据表明，观察到的明显低胆固醇血症不受肿瘤病理分期或分化程度的影响。
