Mahesh N, Rahamthullah S A K Uroof, Naidu Guntipalli M, Rajesh Amudala, Babu P Ravisekhar, Reddy J Muralinath
Department of Oral Medicine & Radiology, KLR's Lenora Institute of Dental Sciences, Rajahmundry, Andhra Pradesh, India.
Department of Oral and Maxillofacial Surgery, C K S Theja Institute of Dental Sciences, Tirupati, Andhra Pradesh, India.
J Int Oral Health. 2014 Feb;6(1):78-84. Epub 2014 Feb 26.
Oral cancer is associated initially by the presence of pre-malignant lesions or pre-malignant conditions. Oral Leukoplakia is one of the best-known pre-malignant lesions in the oral cavity that have the highest rate of malignant transformation. Numerous studies have shown an altered lipid profile in various cancers including head and neck cancers. An inverse relationship between plasma lipid profiles has been seen in oral cancer and pre-cancerous subjects. The present study evaluated the plasma lipid profiles in oral leukoplakia and controls.
MATERIALS & METHODS: This study was done in department of Oral Medicine and Radiology, Sibar dental College and Konacc diagnostics. 30 patients were included in the study (15 patients with oral leukoplakia (histo-pathologically proven) and 15 patients for comparison of results as controls). Patients with cardiovascular diseases, uncontrolled diabetes mellitus, acute hepatitis and nephrosis were excluded from the sample and lipid profile assay was done by fully automated biochemistry analyser (EM-360). Paired-t and Scheffe tests were used to find statistical significance between two groups.
The plasma lipid levels were estimated in between the two groups by arithmetic mean along with standard deviation. The lipid parameters included were Total cholesterol, HDL, LDL, VLDL, Triglycerides. The lipid parameters of the patients in between the two groups were compared and analysed.
In this study TC, HDL, LDL, Triglyceride level analysis showed slightly lower levels in oral leukoplakia patients than that of the controls. Higher VLDL levels were observed in leukoplakia than the control group. How to cite the article: Mahesh N, Rahamthullah SA, Naidu GM, Rajesh A, Babu PR, Reddy JM. Alterations of Plasma lipid profile patterns in oral leukoplakia. J Int Oral Health 2014;6(1):78-84.
口腔癌最初与癌前病变或癌前状态的存在有关。口腔白斑是口腔中最著名的癌前病变之一，其恶性转化率最高。众多研究表明，包括头颈癌在内的各种癌症中脂质谱均发生改变。在口腔癌和癌前病变患者中观察到血浆脂质谱呈负相关。本研究评估了口腔白斑患者和对照组的血浆脂质谱。
本研究在西巴尔牙科学院口腔医学与放射科及科纳克诊断中心进行。30名患者纳入研究（15名经组织病理学证实的口腔白斑患者以及15名作为对照用于结果比较的患者）。患有心血管疾病、未控制的糖尿病、急性肝炎和肾病的患者被排除在样本之外，脂质谱分析通过全自动生化分析仪（EM - 360）完成。采用配对t检验和谢费检验来确定两组之间的统计学显著性。
通过算术平均值及标准差对两组之间的血浆脂质水平进行评估。所纳入的脂质参数包括总胆固醇、高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白、甘油三酯。对两组患者的脂质参数进行比较和分析。
在本研究中，总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯水平分析显示，口腔白斑患者的这些水平略低于对照组。白斑患者的极低密度脂蛋白水平高于对照组。如何引用本文：Mahesh N, Rahamthullah SA, Naidu GM, Rajesh A, Babu PR, Reddy JM.口腔白斑患者血浆脂质谱模式的改变。《国际口腔健康杂志》2014年；6(1):78 - 84。
