Department of Epidemiology and Health Statistics, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Thorax. 2024 Jan 18;79(2):179-181. doi: 10.1136/thorax-2023-220012.
Smoking has been considered a risk factor for idiopathic pulmonary fibrosis (IPF) in observational studies. To assess whether smoking plays a causal role in IPF, we performed a Mendelian randomization study using genetic association data of 10 382 cases with IPF and 968 080 controls. We found that genetic predisposition to smoking initiation (based on 378 variants) and lifetime smoking (based on 126 variants) were associated with a higher risk of IPF. Our study suggests a potential causal effect of smoking on increasing IPF risk from a genetic perspective.
在观察性研究中，吸烟被认为是特发性肺纤维化（IPF）的一个风险因素。为了评估吸烟是否在 IPF 中起因果作用，我们使用了 10382 例 IPF 患者和 968080 例对照的遗传关联数据进行了孟德尔随机化研究。我们发现，吸烟起始的遗传易感性（基于 378 个变异体）和终生吸烟（基于 126 个变异体）与 IPF 风险的增加相关。我们的研究从遗传角度表明了吸烟对增加 IPF 风险的潜在因果效应。
