脑特异性调节性 T 细胞扩增限制认知能力下降。

Brain-specific regulatory T cell expansion limits cognitive decline.

机构信息

Vall d'Hebron Research Institute (VHIR). Universitat Autónoma de Barcelona, Barcelona, 08035, Spain.

Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, 03010, Spain; Instituto de Neurosciencias CSIC-UMH, San Juan de Alicante, 03550, Spain.

出版信息

Trends Mol Med. 2023 Jul;29(7):481-483. doi: 10.1016/j.molmed.2023.05.001. Epub 2023 May 20.

DOI:10.1016/j.molmed.2023.05.001

PMID:37217360

Abstract

Recent work from Lemaitre and colleagues leveraged a central nervous system (CNS)-specific gene delivery approach to expand regulatory T cells (Treg) in aged mice. CNS-restricted Treg expansion reversed age-related glial cell transcriptomic changes and prevented aspects of cognitive decline, unveiling immune modulation as a potential approach to protect cognitive function with age.

摘要

最近，Lemaitre 和同事们利用一种中枢神经系统（CNS）特异性基因传递方法来扩增老年小鼠中的调节性 T 细胞（Treg）。CNS 限制的 Treg 扩增逆转了与年龄相关的神经胶质细胞转录组变化，并防止了认知能力下降的某些方面，揭示了免疫调节作为一种潜在的方法，可随着年龄的增长保护认知功能。