产前产妇败血症的预测因素及其对新生儿结局的影响：一项基于人群的队列研究。
Predictors of antepartum maternal sepsis and effects on neonatal outcomes: a population-based cohort study.
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.
Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
出版信息
J Perinatol. 2023 Jun;43(6):752-757. doi: 10.1038/s41372-023-01696-3. Epub 2023 May 22.
OBJECTIVE
To examine the relationship between maternal sepsis, type of infection, and short-term neonatal outcomes.
STUDY DESIGN
We conducted a retrospective cohort study investigating pregnancies between 2005 and 2008 in California with antepartum maternal sepsis diagnosis. Comparisons were made between sepsis cases and controls, using chi-squared or Fisher's exact test. Multivariable logistic regression was performed, adjusting for maternal characteristics.
RESULTS
Several maternal characteristics were associated with increased odds of maternal sepsis. Both obstetric and non-obstetric infections were associated with maternal sepsis (p < 0.001). The positive predictive value of maternal sepsis for preterm delivery was 55.03%. Neonates born to maternal sepsis patients had a higher risk of developing neonatal complications including neonatal shock.
CONCLUSION
Maternal sepsis was associated with neonatal complications. Efforts to reduce maternal sepsis may improve neonatal outcomes. Further studies are required for a better understanding of these associations and whether prevention or more rapid diagnosis and treatment can lower these risks.
目的
探讨母体败血症、感染类型与短期新生儿结局之间的关系。
研究设计
我们进行了一项回顾性队列研究，调查了 2005 年至 2008 年加利福尼亚州的产前母体败血症诊断病例。使用卡方检验或 Fisher 确切检验比较败血症病例与对照组。采用多变量逻辑回归，调整了母体特征。
结果
一些母体特征与母体败血症的发生几率增加有关。产科和非产科感染均与母体败血症相关（p<0.001）。母体败血症预测早产的阳性预测值为 55.03%。母体败血症患者所生的新生儿发生新生儿并发症（包括新生儿休克）的风险更高。
结论
母体败血症与新生儿并发症有关。努力降低母体败血症的发生率可能会改善新生儿结局。需要进一步研究以更好地理解这些关联，以及预防或更快的诊断和治疗是否可以降低这些风险。
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