Department of Chemistry, Indian Institute of Technology (IIT), Hyderabad, Kandi, Sangareddy - 502284, Telangana, India.
Chem Commun (Camb). 2023 Jun 6;59(46):7084-7087. doi: 10.1039/d3cc01050c.
Herein, we report the first microwave-assisted remote-C-H functionalization aided by a simple nitrile directing template. Notably, the present protocol showed a broad substrate scope enabling -C-H arylation, acetoxylation, and cyanation. Significantly, the microwave-accelerated -C-H functionalization was effective with short reaction times without compromising yields and site selectivity. In addition, ibuprofen drug diversification was accomplished by carrying out arylation, acetoxylation, and cyanation. Importantly, -dual-hetero functionalization has been presented.
本文报道了首例通过简单腈导向模板辅助的微波辅助远程 C-H 功能化。值得注意的是，本方案具有广泛的底物范围，能够实现 -C-H 芳基化、乙酰氧基化和氰基化。显著的是，微波加速的 -C-H 功能化反应时间短，产率和位点选择性高。此外，通过进行芳基化、乙酰氧基化和氰基化，实现了布洛芬药物的多样化。重要的是，还提出了 - 双重杂芳基化。
