Division of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Republic of Korea.
Department of Food Science and Human Nutrition and K-Food Research Center, Jeonbuk National University, Jeonju 54986, Republic of Korea.
J Microbiol Biotechnol. 2023 May 28;33(5):680-686. doi: 10.4014/jmb.2302.02022. Epub 2023 Mar 10.
Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using as an in vivo model system, we identified extract (CPE) as a novel anti-aging substance. Regardless of sex, treated with CPE showed a significantly increased lifespan compared to those without CPE. In this study, we also evaluated the involvement of CPE in aging-related biochemical pathways, including TOR, stem cell generation, and antioxidative effects, and found that the representative genes of each pathway were induced by CPE administration. CPE administration did not result in significant differences in fecundity, locomotion, feeding amount, or TAG level. These conclusions suggest that CPE is a good candidate as an anti-aging food substance capable of promoting a healthy lifespan.
衰老是各种生物体中发生的一系列复杂的多器官过程。因此，有必要使用衰老动物模型进行体内研究，以确定其确切的机制并识别抗衰老物质。我们使用 作为体内模型系统，鉴定出 提取物（CPE）是一种新型的抗衰老物质。无论性别如何，用 CPE 处理的 都显示出比没有 CPE 的 寿命显著延长。在这项研究中，我们还评估了 CPE 在与衰老相关的生化途径中的参与情况，包括 TOR、干细胞生成和抗氧化作用，并发现每个途径的代表性基因都被 CPE 给药诱导。CPE 给药不会导致生育力、运动能力、摄食量或 TAG 水平的显著差异。这些结论表明，CPE 是一种有前途的抗衰老食品物质，能够促进健康的寿命。
