头颈部孤立性纤维性肿瘤：国家癌症数据库综述
Head and neck solitary fibrous tumors: A review of the National Cancer Database.
作者信息
Abiri Arash, Nguyen Cecilia, Latif Kareem, Goshtasbi Khodayar, Torabi Sina J, Birkenbeuel Jack L, Kuan Edward C
机构信息
Department of Otolaryngology - Head and Neck Surgery, University of California, Irvine, Orange, California, USA.
出版信息
Head Neck. 2023 Aug;45(8):1934-1942. doi: 10.1002/hed.27417. Epub 2023 May 23.
BACKGROUND
Head and neck solitary fibrous tumors (SFTs) are rare neoplasms, with few large-scale studies describing this entity. We evaluated the demographics and correlates of survival in a large series of SFT patients.
METHODS
The 2004-2017 National Cancer Database was queried for head and neck SFT patients receiving definitive surgery. Cox proportional-hazards and Kaplan-Meier analyses assessed overall survival (OS).
RESULTS
Of 135 patients, sinonasal (33.1%) and orbital (25.9%) SFTs were most common. Approximately 93% of SFTs were invasive and 64% were classified as hemangiopericytomas. The 5-year OS of skull base SFTs (84.5%) was lower than sinonasal (98.7%) and orbital (90.7%) SFTs (all p < 0.05). Government insurance exhibited higher mortality (HR 5.116; p < 0.001) and lower OS (p = 0.001).
CONCLUSION
Head and neck SFTs presented with distinct prognoses based on anatomical origin. Overall survival was particularly worse in patients with skull base SFTs or government insurance. Prognostically, hemangiopericytomas were indistinct from other SFTs.
背景
头颈部孤立性纤维瘤（SFTs）是罕见肿瘤，很少有大规模研究描述这一实体。我们评估了一大系列SFT患者的人口统计学特征及生存相关因素。
方法
查询2004 - 2017年国家癌症数据库中接受根治性手术的头颈部SFT患者。采用Cox比例风险模型和Kaplan - Meier分析评估总生存期（OS）。
结果
135例患者中，鼻窦（33.1%）和眼眶（25.9%）SFT最为常见。约93%的SFT具有侵袭性，64%被归类为血管外皮细胞瘤。颅底SFT的5年总生存率（84.5%）低于鼻窦（98.7%）和眼眶（90.7%）SFT（所有p < 0.05）。政府医保患者死亡率更高（HR 5.116；p < 0.001），总生存期更低（p = 0.001）。
结论
头颈部SFTs根据解剖起源呈现出不同的预后。颅底SFTs患者或有政府医保的患者总生存期尤其较差。在预后方面，血管外皮细胞瘤与其他SFTs并无明显差异。
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