Li Yuan, Hou Xiujuan, Liu Shengyan, Lu Siyi, Du Mengmeng, Dong Xia, Liu Xiaoping, Li Chen
School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China.
Department of Rheumatology, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, China.
Int J Rheum Dis. 2023 Nov;26(11):2304-2309. doi: 10.1111/1756-185X.14740. Epub 2023 May 23.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune inflammatory disease characterized by osteoarticular and dermatological manifestations. The most common osteoarticular manifestations involve the anterior chest wall, axial skeleton, and long bones. Cranial bone involvement is less reported in SAPHO syndrome. We herein present three cases of SAPHO syndrome with cranial bone involvement, and review the previous literature on similar manifestations. It was revealed that SAPHO syndrome could lead to cranial bone involvement, which could involve the dura mater, leading to hypertrophic pachymeningitis, but the outcome is usually good. Janus kinase inhibitors may be a potential treatment option.
滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征是一种罕见的自身免疫性炎症性疾病，其特征为骨关节和皮肤表现。最常见的骨关节表现累及前胸壁、中轴骨骼和长骨。SAPHO综合征中颅骨受累的报道较少。我们在此报告3例伴有颅骨受累的SAPHO综合征病例，并回顾以往关于类似表现的文献。结果显示，SAPHO综合征可导致颅骨受累，可累及硬脑膜，导致肥厚性硬脑膜炎，但预后通常良好。Janus激酶抑制剂可能是一种潜在的治疗选择。
