Department of Dermatology, Soonchunhyang University College of Medicine, Cheonan, South Korea.
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.
J Cosmet Dermatol. 2023 Dec;22(12):3375-3378. doi: 10.1111/jocd.15829. Epub 2023 May 23.
In any dermatologic procedure, patient acceptance of treatment is heavily influenced by intraprocedural pain. Intralesional triamcinolone injections are very important in keloid scar and nodulocystic acne treatment. However, the main problem of needle-stick procedures is pain. Cryoanesthesia is ideally intended to cool only the epidermis during treatment and has advantage which did not require application time.
The aim of this study was to investigate the pain-reducing effect and safety of CryoVIVE® (newly introduced cryoanesthesia device) during triamcinolone injections for nodulocystic acne in actual clinical settings.
PATIENTS/METHODS: In this two-staged, non-randomized clinical trial, a total of 64 subjects underwent intralesional triamcinolone injections for their acne lesions with cold anesthesia using CryoVIVE®. The pain intensity was assessed with Visual Analogue Scale (VAS) scores. Safety profile was also evaluated.
The mean pain VAS scores on the lesion with and without cold anesthesia were 3.667 and 5.933, respectively (p = 0.0001). No side effects, discoloration, and scarring were observed.
In conclusion, the anesthetic use of CryoVIVE® with intralesional corticosteroid injections is a practical and well-tolerated modality.
在任何皮肤科治疗过程中，患者对治疗的接受程度都受到术中疼痛的严重影响。病灶内注射曲安奈德在瘢痕疙瘩和结节囊肿性痤疮的治疗中非常重要。然而，针刺痛的主要问题是疼痛。冷冻麻醉的理想目的是在治疗过程中只冷却表皮，具有无需应用时间的优势。
本研究旨在探讨 CryoVIVE®（新引入的冷冻麻醉设备）在结节囊肿性痤疮的曲安奈德注射中的镇痛效果和安全性。
患者/方法：在这项两阶段、非随机临床试验中，共 64 名患者接受了使用 CryoVIVE®进行的冷麻醉下的病灶内曲安奈德注射治疗。使用视觉模拟评分法（VAS）评估疼痛强度。还评估了安全性。
有和没有冷麻醉时病变的平均疼痛 VAS 评分分别为 3.667 和 5.933（p=0.0001）。未观察到任何副作用、变色和瘢痕形成。
总之，CryoVIVE®与病灶内皮质类固醇注射联合应用麻醉是一种实用且耐受性良好的方法。
