Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Dongjak-gu, Seoul, South Korea.
Department of Dermatology, Chungnam National University Sejong Hospital, Sejong, South Korea.
Skin Res Technol. 2024 Sep;30(9):e70045. doi: 10.1111/srt.70045.
Acne vulgaris poses a significant dermatological challenge, necessitating alternative treatments due to limitations and side effects associated with current therapies. This pilot clinical trial investigated the feasibility and efficacy of precision cryotherapy for acne vulgaris.
A total of 20 volunteers underwent targeted precision cryotherapy using a carbon dioxide-based device. Treatment outcomes were assessed using various parameters, including Investigator Global Assessment (IGA) score, acne lesion count, erythema index (EI), global evaluation score, and participant satisfaction. Safety monitoring included adverse event reporting and physical examination.
Precision cryotherapy demonstrated a significant reduction (90.25%) in the acne lesion count by week 4, with clinical improvement indicated by IGA score reduction (p < 0.001). The EI showed notable improvements at weeks 1, 2, and 4. The global evaluation score demonstrated a 75%-100% clinical improvement at Visit 4. Participants reported high satisfaction (6.75 ± 0.79) with the procedure. No adverse event or discomfort was reported.
Precision cryotherapy effectively improved acne lesions, which was safe and satisfactory for participants. These findings suggest its potential as an alternative therapeutic modality, especially for populations with limited treatment options. Further research is needed to validate the results and explore underlying mechanisms.
寻常痤疮是一种严重的皮肤挑战，由于当前疗法的局限性和副作用，需要替代治疗。本临床研究旨在探索精准冷冻治疗寻常痤疮的可行性和疗效。
20 名志愿者使用基于二氧化碳的设备接受靶向精准冷冻治疗。采用多项参数评估治疗效果，包括研究者总体评估（IGA）评分、痤疮皮损计数、红斑指数（EI）、总体评估评分和患者满意度。安全性监测包括不良事件报告和体格检查。
第 4 周时，痤疮皮损计数显著减少（90.25%），IGA 评分降低表明临床改善（p<0.001）。EI 在第 1、2 和 4 周时明显改善。第 4 次就诊时，总体评估评分显示 75%-100%的临床改善。患者对治疗过程非常满意（6.75±0.79）。未报告不良事件或不适。
精准冷冻治疗能有效改善痤疮皮损，对患者安全且满意度高。这些结果提示其作为一种替代治疗方法的潜力，特别是对治疗选择有限的人群。需要进一步研究以验证结果并探讨潜在机制。
