手性 3,3,3',3'-四甲基-1,1'-螺双茚基环戊二烯基（TMSCp）配体：设计、合成与应用。
Chiral 3,3,3',3'-Tetramethyl-1,1'-Spirobiindanyl Cyclopentadienyl (TMSCp) Ligands: Design, Synthesis, and Applications.
机构信息
Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-Sen University, Guangzhou 510006, P. R. China.
出版信息
Org Lett. 2023 Jun 2;25(21):3823-3828. doi: 10.1021/acs.orglett.3c00941. Epub 2023 May 23.
Chiral cyclopentadienyl (Cp) rhodium(III) are powerful catalysts for achieving asymmetric C-H activation. This paper describes the design and synthesis of a new type of chiral Cp ligand bearing a chiral 3,3,3',3'-tetramethyl-1,1'-spirobiindanyl backbone. It features convenient synthesis, easy modification, and relatively low cost. Moreover, it holds great potential in achieving asymmetric C-H activation as exemplified by four examples examined in this work.
手性环戊二烯基（Cp）铑（III）是实现不对称 C-H 活化的有力催化剂。本文描述了一种新型手性 Cp 配体的设计和合成，该配体具有手性 3,3,3',3'-四甲基-1,1'-螺[茚满]-2,2'-二基骨架。它具有合成方便、易于修饰和相对较低成本的特点。此外，它在实现不对称 C-H 活化方面具有很大的潜力，本文通过四个实例进行了验证。
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