职业性接触抗肿瘤药物对护士不良妊娠结局的影响：荟萃分析。
Influence of occupational exposure to antineoplastic agents on adverse pregnancy outcomes among nurses: A meta-analysis.
机构信息
Clinical Medical College of Shenzhen, Guangzhou University of Chinese Medicine, Shenzhen, China.
Longgang District Central Hospital of Shenzhen, Shenzhen, China.
出版信息
Nurs Open. 2023 Sep;10(9):5827-5837. doi: 10.1002/nop2.1853. Epub 2023 May 23.
AIM
This study aimed to explore the relationship between nurses' occupational exposure to antineoplastic agents and adverse pregnancy outcomes.
DESIGN
Meta-analysis.
METHODS
Data were retrieved from studies published before April 2022 in PubMed, the Cochrane Library, the Web of Science, Embase databases, the China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), China Science and Technology Journal databases (VIP) and Wan Fang databases (WF). Stata MP (Version 17.0) was used to conduct this meta-analysis.
RESULTS
The current evidence shows that occupational exposure to antineoplastic agents increases nurses' risk of spontaneous abortions, stillbirths, and congenital abnormalities. It is necessary to pay attention to occupational exposures caused by antineoplastic agents, especially for female nurses of reproductive age. Managers should take timely and effective countermeasures to ensure their occupational safety and reduce the risk of adverse pregnancy outcomes.
目的
本研究旨在探讨护士职业性接触抗肿瘤药物与不良妊娠结局之间的关系。
设计
荟萃分析。
方法
数据来源于 2022 年 4 月前在 PubMed、Cochrane 图书馆、Web of Science、Embase 数据库、中国知网（CNKI）、中国生物医学文献数据库（CBM）、中国科技期刊数据库（VIP）和万方数据库（WF）上发表的研究。采用 Stata MP（版本 17.0）进行荟萃分析。
结果
目前的证据表明，职业性接触抗肿瘤药物会增加护士发生自然流产、死胎和先天畸形的风险。需要关注抗肿瘤药物引起的职业暴露，特别是对处于生育年龄的女性护士。管理者应采取及时有效的对策，确保其职业安全，降低不良妊娠结局的风险。
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