National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
Am J Obstet Gynecol. 2012 Apr;206(4):327.e1-8. doi: 10.1016/j.ajog.2011.12.030. Epub 2011 Dec 30.
We investigated self-reported occupational exposure to antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents (disinfectants), and X-rays and the risk of spontaneous abortion in US nurses.
Pregnancy outcome and occupational exposures were collected retrospectively from 8461 participants of the Nurses' Health Study II. Of these, 7482 were eligible for analysis using logistic regression.
Participants reported 6707 live births, and 775 (10%) spontaneous abortions (<20 weeks). After adjusting for age, parity, shift work, and hours worked, antineoplastic drug exposure was associated with a 2-fold increased risk of spontaneous abortion, particularly with early spontaneous abortion before the 12th week, and 3.5-fold increased risk among nulliparous women. Exposure to sterilizing agents was associated with a 2-fold increased risk of late spontaneous abortion (12-20 weeks), but not with early spontaneous abortion.
This study suggests that certain occupational exposures common to nurses are related to risks of spontaneous abortion.
我们调查了美国护士自述的抗肿瘤药物、麻醉气体、抗病毒药物、消毒剂（杀菌剂）和 X 射线职业暴露与自然流产的风险。
从护士健康研究 II 的 8461 名参与者中回顾性收集妊娠结局和职业暴露数据。其中，7482 名参与者可通过逻辑回归进行分析。
参与者报告了 6707 例活产，775 例（10%）自然流产（<20 周）。调整年龄、产次、轮班工作和工作时间后，抗肿瘤药物暴露与自然流产风险增加 2 倍相关，尤其是在 12 周之前的早期自然流产，以及未产妇的自然流产风险增加 3.5 倍。消毒剂暴露与晚期自然流产（12-20 周）风险增加 2 倍相关，但与早期自然流产无关。
这项研究表明，护士常见的某些职业暴露与自然流产的风险有关。
