Yang Li-Hua, Liu Li-Ping, Jiang Fa-Ying, Huang Feng-Zhu, Xie Chun-Fen, Lin Xue-Qin, Wang Pan, Feng Xiu-Li
Department of Neurology, Panyu Branch, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Outpatient, Panyu Branch, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Front Oncol. 2025 Mar 6;15:1539389. doi: 10.3389/fonc.2025.1539389. eCollection 2025.
This study aimed to address the challenges associated with antineoplastic drug extravasation during intravenous administration, through the development of a novel chemotherapy infusion device. A secondary objective was to mitigate associated risks to healthcare personnel, patients, caregivers and the environment.
A water-soluble fluorescent solution was used as a surrogate for antineoplastic chemotherapy agents to assess the potential for drug extravasation and the associated risks of occupational exposure during intravenous administration. The investigation identified risks related to drug extravasation, which informed the development of the novel infusion device.
In experiment 1, conventional methods for replacing infusion bags resulted in drug extravasation during the second bag change across all procedures conducted by 9 operators. Specifically, extravasation was observed in 81 out of 90 procedures. In experiment 2, the newly designed multifunctional chemotherapy infusion device, which requires each infusion bag to be punctured only once, was used. Under these conditions, the same 9 operators performed 90 procedures, with extravasation occurring in only 2 instances.
The multifunctional chemotherapy infusion device facilitates the efficient administration of intravenous chemotherapy while addressing the issue of drug extravasation associated with traditional infusion devices during the delivery of antineoplastic drugs. This device effectively reduces the risk of occupational injuries among healthcare workers, reduces harm to patients and their caregivers, and mitigates environmental contamination.
本研究旨在通过开发一种新型化疗输液装置，应对静脉给药过程中与抗肿瘤药物外渗相关的挑战。次要目标是减轻对医护人员、患者、护理人员和环境的相关风险。
使用水溶性荧光溶液作为抗肿瘤化疗药物的替代物，以评估静脉给药期间药物外渗的可能性以及职业暴露的相关风险。该调查确定了与药物外渗相关的风险，为新型输液装置的开发提供了依据。
在实验1中，更换输液袋的传统方法导致9名操作人员进行的所有操作在更换第二个袋子时均出现药物外渗。具体而言，90次操作中有81次观察到外渗。在实验2中，使用了新设计的多功能化疗输液装置，该装置每个输液袋只需穿刺一次。在这些条件下，同样的9名操作人员进行了90次操作，仅2次出现外渗。
多功能化疗输液装置有助于高效进行静脉化疗，同时解决了抗肿瘤药物给药过程中与传统输液装置相关的药物外渗问题。该装置有效降低了医护人员职业伤害的风险，减少了对患者及其护理人员的伤害，并减轻了环境污染。
