烯烃的氧化三元硒官能化反应：邻位官能化硒化物的方便合成方法。
Oxidative Three-Component Selenofunctionalization of Alkenes: Convenient Access to Vicinally Functionalized Selenides.
机构信息
School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226019, People's Republic of China.
出版信息
J Org Chem. 2023 Jun 2;88(11):7431-7447. doi: 10.1021/acs.joc.3c00788. Epub 2023 May 23.
Three-component selenofunctionalization processes of olefins, diselenides and sulfonamides, water, alcohols, or acids utilizing 1-fluoropyridinium triflate (FP-OTf) as a reaction promoter are reported. Under the optimal conditions, a broad range of vicinally functionalized selenide derivatives was accessible with high yields and excellent functional group compatibilities. Mechanistic studies revealed that the FP-OTf played a key role in this selenofunctionalization process.
报道了利用 1-氟吡啶三氟甲磺酸酯（FP-OTf）作为反应促进剂，实现烯烃、二硒醚和磺酰胺与水、醇或酸的三元硒官能化反应。在最优条件下，广泛的邻位官能化硒化物衍生物可以高产率和优异的官能团兼容性获得。机理研究表明，FP-OTf 在该硒官能化过程中起关键作用。
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