Won Junyeon, Nielson Kristy A, Smith J Carson
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA.
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Alzheimers Dis Rep. 2023 May 12;7(1):399-413. doi: 10.3233/ADR-220062. eCollection 2023.
Despite growing evidence regarding the association between exercise training (ET) and functional brain network connectivity, little is known about the effects of ET on large-scale within- and between-network functional connectivity (FC) of core brain networks.
We investigated the effects of ET on within- and between-network functional connectivity of the default mode network (DMN), frontoparietal network (FPN), and salience network (SAL) in older adults with intact cognition (CN) and older adults diagnosed with mild cognitive impairment (MCI). The association between ET-induced changes in FC and cognitive performance was examined.
33 older adults (78.0±7.0 years; 16 MCI and 17 CN) participated in this study. Before and after a 12-week walking ET intervention, participants underwent a graded exercise test, Controlled Oral Word Association Test (COWAT), Rey Auditory Verbal Learning Test (RAVLT), a narrative memory test (logical memory; LM), and a resting-state fMRI scan. We examined the within () and between () network connectivity of the DMN, FPN, and SAL. We used linear regression to examine associations between ET-related changes in network connectivity and cognitive function.
There were significant improvements in cardiorespiratory fitness, COWAT, RAVLT, and LM after ET across participants. Significant increases in DMN and SAL, and DMN-FPN, DMN-SAL, and FPN-SAL were observed after ET. Greater SAL and FPN-SAL were associated with enhanced LM immediate recall performance after ET in both groups.
Increased within- and between-network connectivity following ET may subserve improvements in memory performance in older individuals with intact cognition and with MCI due to Alzheimer's disease.
尽管越来越多的证据表明运动训练（ET）与大脑功能网络连通性之间存在关联，但对于ET对核心脑网络大规模内部和网络间功能连通性（FC）的影响知之甚少。
我们研究了ET对认知功能正常（CN）的老年人和被诊断为轻度认知障碍（MCI）的老年人默认模式网络（DMN）、额顶叶网络（FPN）和突显网络（SAL）内部和网络间功能连通性的影响。研究了ET引起的FC变化与认知表现之间的关联。
33名老年人（78.0±7.0岁；16名MCI患者和17名CN患者）参与了本研究。在进行为期12周的步行ET干预前后，参与者接受了分级运动测试、控制口语单词联想测试（COWAT）、雷伊听觉词语学习测试（RAVLT）、叙事记忆测试（逻辑记忆；LM）和静息态功能磁共振成像扫描。我们检查了DMN、FPN和SAL的网络内（）和网络间（）连通性。我们使用线性回归来研究网络连通性与ET相关变化和认知功能之间的关联。
ET后，所有参与者的心肺适能、COWAT、RAVLT和LM均有显著改善。ET后观察到DMN和SAL以及DMN-FPN、DMN-SAL和FPN-SAL显著增加。两组中，更大的SAL和FPN-SAL与ET后增强的LM即时回忆表现相关。
ET后网络内和网络间连通性的增加可能有助于改善认知功能正常和患有阿尔茨海默病所致MCI的老年人的记忆表现。
